Results 211 to 220 of about 26,834 (239)

TRPV1 in migraine pathophysiology

Trends in Molecular Medicine, 2010
Migraine is among the most prevalent headache disorders and results from dysfunctions within the trigeminovascular system (TVS). The inflammatory processes that have been suggested to occur in the cascade of events resulting in migraine sensitise trigeminal nociceptors, possibly causing hyperalgesia and allodynia.
Jannis E, Meents, Lars, Neeb, Uwe, Reuter   +2 more
openaire   +2 more sources

Structure and function of TRPV1

Pflügers Archiv - European Journal of Physiology, 2005
Capsaicin, the main ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), is predicted to have six transmembrane (TM) domains and a short, pore ...
Makoto, Tominaga, Tomoko, Tominaga
openaire   +2 more sources

Optical Control of TRPV1 Channels

Angewandte Chemie - International Edition, 2013
Marco Stein, Andreas Breit, Timm Fehrentz   +2 more
exaly   +3 more sources

Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant

American Journal of Physiology-Renal Physiology, 2006
The capsaicin receptor and transient receptor potential channel TRPV1 senses heat, protons, and vanilloid agonists in peripheral sensory ganglia. Abundant data have suggested the presence of potentially novel splice variants in the kidney. We report a novel rat TRPV1 splice variant, TRPV1VAR, cloned from kidney papilla. TRPV1VAR cDNA was identified in
Wei, Tian, Yi, Fu, Donna H, Wang, David M, Cohen   +3 more
openaire   +2 more sources

TRPV1: A potential target for antiepileptogenesis

Medical Hypotheses, 2009
Epilepsy is one of the most common diseases in neurology department. It is caused by many different kinds of perturbances of normal balance of excitation and inhibition within the central nervous system. Current clinical antiepileptic drugs (AEDs) targets include ion channels, neurotransmitter transporters and neurotransmitter metabolic enzymes.
Min, Fu, Zuoping, Xie, Huancong, Zuo
openaire   +2 more sources

Synthesis of a TRPV1 Receptor Antagonist

The Journal of Organic Chemistry, 2009
A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1.
Su, Yu, Anthony, Haight, Brian, Kotecki, Lei, Wang, Kirill, Lukin, David R, Hill   +5 more
openaire   +2 more sources

TRPV1 Function in Health and Disease

Current Pharmaceutical Biotechnology, 2011
The transient receptor potential vanilloid type 1 ion channel (TRPV1) was identified as a receptor responsible for mediating the intense burning sensation following exposure to heat greater than approximately 43°C., or capsaicin, the pungent ingredient of hot chilli peppers.
John P M, White, Laszlo, Urban, Istvan, Nagy   +2 more
openaire   +2 more sources

Assay of TRPV1 Receptor Signaling

2016
The transient receptor potential vanilloid-1 ion channel (TRPV1) is a non-selective ligand-gated cation channel. It is an integrator of a wide variety of exogenous and endogenous physical and chemical stimuli, including capsaicin, noxious heat (>42 °C), and protons (pH 
Schiano Moriello Aniello, De Petrocellis Luciano   +1 more
openaire   +3 more sources

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

Cell, 2021
Kaihua Zhang, David Julius, Yifan Cheng   +2 more
exaly  

TRPV1 modulação

  Em meus estudos, observei que o segredo para modular o TRPV1 de forma segura e eficaz reside em trabalhar com moléculas que possuem massa molar entre 200 e 250 g/mol — uma faixa que parece quase mágica para equilibrar potência, seletividade e tolerabilidade.
openaire   +2 more sources