Results 141 to 150 of about 1,008,370 (159)

Blockade of TRPV channels by intracellular spermine [PDF]

Journal of General Physiology, 2023
The Vanilloid thermoTRP (TRPV1-4) subfamily of TRP channels are involved in thermoregulation, osmoregulation, itch and pain perception, (neuro)inflammation and immune response, and tight control of channel activity is required for perception of noxious ...
Grigory Maksaev, Colin Nichols
exaly   +2 more sources

Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis

Cells, 2020
It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
V'Yacheslav Lehen'Kyi, Aurélien Haustrate, V’Yacheslav Lehen’Kyi   +2 more
exaly   +2 more sources

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Transient receptor potential cation channel subfamily V (TRPV) and its importance in asthma.

European Journal of Pharmacology, 2022
Transient receptor potential (TRP) ion channels play critical roles in physiological and pathological conditions. Increasing evidence has unveiled the contribution of TRP vanilloid (TRPV) family in the development of asthma. The TRPV family is a group (TRPV1-TRPV6) of polymodal channels capable of sensing thermal, acidic, mechanical stress, and osmotic
Jorge, Reyes-García, Abril, Carbajal-García, Luis M, Montaño   +2 more
openaire   +2 more sources

TRPV Channels in Osteoarthritis: A Comprehensive Review

Biomolecules
Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete.
Bin Geng, Chen Rongjin, Changshun Chen   +2 more
exaly   +2 more sources

A novel actor in mechanotransduction: transient receptor potential cation channel vanilloid (TRPV) 1 in ventilator‐induced lung injury (VILI)

The FASEB Journal, 2017
Study objective Mechanical ventilation can damage the lung by causing endothelial barrier failure, edema formation and lung injury. Yet, the exact mechanisms underlying the mechanotransduction at the microvascular barrier are still unclear.
Laura Michalick, Wolfgang Liedtke, Wolfgang M. Kuebler   +2 more
openaire   +1 more source

Membrane exchangers of inorganic cations at the human blood-brain barrier : focus on lithium transport and TRPVs channels in human brain endothelial cells

Membrane échangeur de cation inorganique à BBB : focus sur le transport du lithium et les canaux TRPV dans les cellules endothéliales cérébrales humaines Dans un premier temps, nous avons exploré l'effet du lithium sur l'expression des ARNs des transporteurs et des enzymes de métabolisation dans les cellules hCMEC / D3.
openaire   +1 more source

A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

Journal of General Physiology, 2023
Callum M Ives, Ulrich Zachariae
exaly  

Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations

Journal of General Physiology, 2023
Chen Song, Chunhong Liu, Lingfeng Xue
exaly  

Structural insights into the gating mechanisms of TRPV channels

Cell Calcium, 2020
Vera Moiseenkova-Bell, Ruth Pumroy, Tofayel Ahmed   +2 more
exaly  

New Potential Therapies from Vanilloid Transient Receptor Cation (TRPV) Channels.

Current pharmaceutical design, 2008
Di Marzo V, Starowicz K
openaire   +3 more sources