Results 121 to 130 of about 7,490 (202)
Evaluating 5-nitrothiazoles as trypanocidal agents
, 2013 s.r.wilkinson@qmul.ac ...
Bot, Christopher +6 more
openaire +2 more sources
Chemical Communications, 2018 C–H oxygenation of quinones by weak O-coordination was achieved by versatile ruthenium(ii) catalysis with ample substrate scope and trypanocidal compounds were also identified.
Gleiston G. Dias +6 more
openaire +4 more sources
Synthesis of Novel Acetamidobenzanilides Derivatives as Potencial Trypanocidal Agents
Abstract A simple synthesis of novel N-(2-[N’-acetamidomethyl])benzanilides derivatives from 2-nitrobenzaldehyde in a four steps process is described. The 1H-NMR and 13C-NMR spectra were meticulously analyzed to characterize their structure and it was observed that derivatives with an ortho-substituted phenyl group exhibited detectable ...
Valentín I. Ortellado +9 more
openaire +1 more source
Scientia PharmaceuticaChagas disease, caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi), represents a worldwide public health issue. To date, there is no efficient treatment to combat this pathology, and the only drugs available are usually toxic to the patient ...
Miguel A. Uc-Chuc +5 more
doaj +1 more source
Journal of Natural ProductsThe present review article recapitulates for the first time the antipathogenic biological data of a series of lipidic natural products and synthetic analogues thereof characterized by the presence in their structure of an alkynylcarbinol unit. The cytotoxic properties of such natural and bioinspired compounds have been covered by several literature ...
Bouvet, Jon +4 more
openaire +2 more sources
Gossypol: a potential trypanocidal agent [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1985 openaire +3 more sources
Tris(3-methoxypropyl)tin aminobenzoates as potentially trypanocidal agent
, 2004 A set of tris(3-methoxypropyl)tin aminobenzoates and N-(4,6-diamino-1,3,5-triazin-2-yl-)aminobenzoates as compounds with potential trypanocidal activity have been prepared and their solubility in water was determined. On the basis of their 13C and 119Sn NMR spectra and IR spectra, bonding relations in these esters are discussed and a model of the ...
Semenyšínová, Lenka, Handlíř, Karel
openaire +1 more source
[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].
Revista Argentina de microbiologia, 1989 Incubation of Trypanosoma cruzi culture (epimastigote) forms with nifurtimox (10 or 100 microM), benznidazole (38 or 380 microM) and beta-lapachone (1.6 or 7.8 microM) produced damage of nuclear DNA, as shown by the increased rate of the "unscheduled DNA synthesis" in epimastigotes arrested at phase S (9-, 3-, and 6-fold, respectively). alpha-lapachone,
S G, Goijman, A C, Frasch, A O, Stoppani
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Economic analysis of animal disease control inputs at farm level: the case of trypanocide use in villages under risk of drug resistance in West Africa [PDF]
, 2010 This paper presents an economic analysis of the use of drugs (isometamidium and diminazene) in controlling African Animal Trypanosomosis (AAT), a serious disease of cattle and small ruminants in villages that exhibit resistance to isometamidium in ...
Affognon, Hippolyte D. +2 more
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Smallanthus sonchifolius (Yacon) leaves: an emerging source of compounds for diabetes management [PDF]
, 2015 Diabetes mellitus is a chronic metabolic disease that develops mainly due to insulin deficiency or resistance to insulin action. All forms of diabetes are characterized by chronic hyperglycemia, which has an important role in the pathogenesis of diabetic
Genta, Susana Beatriz de Fátima +2 more
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