Results 41 to 50 of about 3,404 (180)

Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:The obligate intracellular protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a neglected illness affecting millions of people in Latin America that recently entered non-endemic countries through immigration, as a ...
Giselle Villa Flor Brunoro, Vitor Marcel Faça, Marcelle Almeida Caminha, André Teixeira da Silva Ferreira, Monique Trugilho, Kelly Cristina Gallan de Moura, Jonas Perales, Richard Hemmi Valente, Rubem Figueiredo Sadok Menna-Barreto   +8 more
doaj   +1 more source

Gossypol: a potential trypanocidal agent Gossypol: um agente potencialmente tripanocida

Revista da Sociedade Brasileira de Medicina Tropical, 1985
Antonio Blanco
openalex   +2 more sources

Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis

Emerging Infectious Diseases, 2012
We describe a case of multiorgan dysfunction secondary to Trypanosoma brucei rhodesiense infection acquired on safari in Zambia. This case was one of several recently reported to ProMED-mail in persons who had traveled to this region.
Lucy E. Cottle, Joanna R. Peters, Alison Hall, J. Wendi Bailey, Harry A. Noyes, Jane E. Rimington, Nicholas J. Beeching, S. Bertel Squire, Mike B.J. Beadsworth   +8 more
doaj   +1 more source

Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies

Molecules, 2017
Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of choice are nifurtimox and benznidazole, but both have severe adverse effects and less effectivity in chronic
Isidro Palos, Edgar E. Lara-Ramirez, Julio Cesar Lopez-Cedillo, Carlos Garcia-Perez, Muhammad Kashif, Virgilio Bocanegra-Garcia, Benjamin Nogueda-Torres, Gildardo Rivera   +7 more
doaj   +1 more source

Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents

Arabian Journal of Chemistry, 2021
Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. Therefore, the search for alternative therapeutic solutions is urgent.
Francisco Salgado, Mauricio Moncada‐Basualto, Josué Pozo-Martínez, Ana Liempi, Ulrike Kemmerling, J.D. Maya, Pablo Jaque, Fernanda Borges, Eugenio Uriarte, María João Matos, Claudio Olea‐Azar   +10 more
openalex   +4 more sources

Additional Evidence of the Trypanocidal Action of (−)-Elatol on Amastigote Forms through the Involvement of Reactive Oxygen Species

Marine Drugs, 2014
Chagas’ disease, a vector-transmitted infectious disease, is caused by the protozoa parasite Trypanosoma cruzi. Drugs that are currently available for the treatment of this disease are unsatisfactory, making the search for new chemotherapeutic agents a ...
Vânia Cristina Desoti, Danielle Lazarin-Bidóia, Daniela Bueno Sudatti, Renato Crespo Pereira, Tania Ueda-Nakamura, Celso Vataru Nakamura, Sueli de Oliveira Silva   +6 more
doaj   +1 more source

2-(Nitroaryl)-5-Substituted-1,3,4-Thiadiazole Derivatives with Antiprotozoal Activities: In Vitro and In Vivo Study

Molecules, 2022
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by a protozoan parasite, Trypanosoma brucei.
Alireza Mousavi, Parham Foroumadi, Zahra Emamgholipour, Pascal Mäser, Marcel Kaiser, Alireza Foroumadi   +5 more
doaj   +1 more source

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Alexandra Ibáñez-Escribano, Cristina Fonseca-Berzal, Mónica Martínez-Montiel, Manuel Álvarez-Márquez, María Gómez-Núñez, Manuel Lacueva-Arnedo, Teresa Espinosa-Buitrago, Tania Martín-Pérez, José Antonio Escario, Penélope Merino-Montiel, Sara Montiel-Smith, Alicia Gómez-Barrio, Óscar López, José G. Fernández-Bolaños   +13 more
doaj   +1 more source

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

Pharmaceuticals, 2022
The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist.
Jessyane Rodrigues do Nascimento, Amanda de Jesus Alves Miranda, Felipe Costa Vieira, Carla Daniele Pinheiro Rodrigues, Luna Nascimento Vasconcelos, José Lima Pereira Filho, Auxiliadora Cristina Corrêa Barata Lopes, Marcelo Marucci Pereira Tangerina, Wagner Vilegas, Cláudia Quintino da Rocha   +9 more
doaj   +1 more source

Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial

Trials, 2019
Background Either benznidazole (BZN) or nifurtimox (NFX) is recommended as equivalent to treat Trypanosoma cruzi infection. Nonetheless, supportive data from randomised trials is limited to individuals treated with BZN in southern cone countries of Latin
Juan Carlos Villar, Víctor Mauricio Herrera, Juan Guillermo Pérez Carreño, Eliana Váquiro Herrera, Yeny Zulay Castellanos Domínguez, Skarlet Marcell Vásquez, Zulma Milena Cucunubá, Nilda Graciela Prado, Yolanda Hernández   +8 more
doaj   +1 more source