Results 1 to 10 of about 102,275 (301)

Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Ribose 5-phosphate isomerase is an enzyme involved in the non-oxidative branch of the pentose phosphate pathway, and catalyzes the inter-conversion of D-ribose 5-phosphate and D-ribulose 5-phosphate.
Inês Loureiro, Joana Faria, Christine Clayton, Sandra Macedo-Ribeiro, Nuno Santarém, Nilanjan Roy, Anabela Cordeiro-da-Siva, Joana Tavares   +7 more
doaj   +2 more sources

Overproduction and Characterization of Recombinant Soluble <i>Trypanosoma brucei</i> Phospholipase A₂. [PDF]

Eng Life Sci
ABSTRACT Trypanosoma brucei phospholipase A2 (TbPLA2) is a validated drug target but the difficulty in expressing its soluble recombinant protein has limited its exploitation for drug and vaccine development for African and American trypanosomiases. We utilized recombinant deoxyribonucleic acid (DNA) technology approaches to express soluble TbPLA2 in ...
Adepoju OA, Quinnell D, Sirohi H, Amlabu E, Sallau AB, Ibrahim A, Atawodi SE, Shuaibu MN, Chang G, Balogun EO.   +9 more
europepmc   +2 more sources

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.

PLoS Pathogens, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn   +4 more
doaj   +2 more sources

Molecular Identification of ABC2 Transporter Gene Encode Protein Ngawi Trypanosoma evansi Isolate that suspected resistance to Isometamidium Chloride [PDF]

BIO Web of Conferences, 2021
This study aims to determine the profile of the ABC2 encoding transporter on Trypanosoma evansi (T. evansi) Ngawi isolates, Indonesia, exposed with Isometamidium Chloride (ISM). This study used blood samples of mice containing Trypanosoma evansi that had
Wusahaningtyas Lu’lu’ Sahara, Nuryady Moh Mirza, Firdausy Lintang Winantya, Fahrurrozi Zs Ahmad, Nurcahyo R. Wisnu   +4 more
doaj   +1 more source

Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei

Nature Microbiology, 2023
Trypanosoma   brucei is a model trypanosomatid, an important group of human, animal and plant unicellular parasites. Understanding their complex cell architecture and life cycle is challenging because, as with most eukaryotic microbes, ~50% of genome ...
K. Billington, C. Halliday, Ross Madden, P. Dyer, A. Barker, F. Moreira-Leite, M. Carrington, S. Vaughan, C. Hertz-Fowler, Samuel Dean, J. Sunter, R. Wheeler, K. Gull   +12 more
semanticscholar   +1 more source

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing

Nature Communications, 2021
Developmental steps in the trypanosome life-cycle involve transition between replicative and non-replicative forms specialised for survival in, and transmission between, mammalian and tsetse fly hosts.
E. Briggs, Federico Rojas, R. McCulloch, K. Matthews, T. Otto   +4 more
semanticscholar   +1 more source

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2021
Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood.
Naiwen Zhang, Ning Jiang, Liying Yu, T. Guan, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen   +7 more
semanticscholar   +1 more source

Trypanosoma brucei brucei

CABI Compendium, 2022
This datasheet on Trypanosoma brucei brucei covers Identity, Vectors & Intermediate Hosts.
D. Gonçalves
semanticscholar   +1 more source

Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa

Frontiers in Veterinary Science, 2021
While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse.
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Gerald Zirintunda, Fred Ssempijja, Bridget Buyinza, Khalid J. Alzahrani, Kevin Matama, Helen N. Nakimbugwe, Helen N. Nakimbugwe, Luay Alkazmi, David Onanyang, Paul Bogere, Juma John Ochieng, Saher Islam, Wycliff Matovu, David Paul Nalumenya, Gaber El-Saber Batiha, Lawrence Obado Osuwat, Mahmoud Abdelhamid, Tianren Shen, Tianren Shen, Leonard Omadang, Susan Christina Welburn, Susan Christina Welburn   +23 more
doaj   +1 more source

Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei

PLoS Pathogens, 2021
Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely extracellularly, in both the blood and interstitial spaces in tissues.
N. Crilly, Monica R. Mugnier
semanticscholar   +1 more source