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Malleable Mitochondrion of Trypanosoma brucei
2015The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology of an early-branching parasitic protist, Trypanosoma brucei, a causative agent of serious human and cattle diseases.
Zdeněk, Verner +15 more
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Tubulin mRNAs of Trypanosoma brucei
Journal of Molecular Biology, 1986The tubulin genes of Trypanosoma brucei are located in a single, tightly packed cluster of ten tandemly arranged alternating alpha and beta-genes. No tubulin genes are detected outside the clustered array. Therefore, the cluster can be assumed to be the locus of tubulin gene expression.
M, Imboden +4 more
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MicroRNA switches in Trypanosoma brucei
Biochemical and Biophysical Research Communications, 2008Trypanosoma brucei develops chronic infection in mammalian hosts due to a sophisticated strategy of antigenic variation of variant surface glycoprotein (VSG) coat to escape antibody-mediated lysis. MicroRNAs are a class of non-coding RNAs with presumed post-transcriptional regulatory activity.
Bibekanand, Mallick +2 more
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Trypanosoma brucei and the nervous system
Trends in Neurosciences, 1994African sleeping sickness, characterized by a peculiar pain syndrome and prominent neuropsychiatric symptoms, is caused by the parasite Trypanosoma brucei (T.b.). In experimental T.b. infections, a molecule released from the trypanosomes has been isolated that binds to the CD8 molecule of T cells, whereby T cells are activated to secrete interferon ...
Bentivoglio M. +3 more
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Cultivation of Dyskinetoplastic Trypanosoma brucei
The Journal of Parasitology, 1980Dyskinetoplastic (Dk) mutant African trypanosomes are able to grow in the mammalian host, but not in the insect host or in culture media in which normal African trypanosomes grow as procyclic trypomastigotes (midgut forms). This inability of Dk mutants to grow as procyclic trypomastigotes is the result of alterations of the kinetoplast (mitochondrial ...
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Protein isoprenylation in Trypanosoma brucei brucei
Biochemical Society Transactions, 1996H, Field +3 more
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Uptake of α-difluoromethylornithine by Trypanosoma brucei brucei
Biochemical Pharmacology, 1986A J, Bitonti +3 more
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Silencing of the thioredoxin gene in Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 2002Armin, Schmidt +2 more
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Acidocalcisome Is Required for Autophagy in Trypanosoma brucei
Autophagy, 2014Cynthia Y He, Feng-Jun Li
exaly

