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Characterisation of pentamidine-resistant Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1995Following selection in vitro by exposure to increasing concentrations of the aromatic diamidine pentamidine, a Trypanosoma brucei brucei clone has been characterised in vivo and in vitro. The resistant clone, designated T.b. brucei S427/118/PR32.6, was found to be less virulent than the parental clone T.b.
Berger, Bradley J. +2 more
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Effect of putrescine on the respiration of Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1986When bloodstream forms of Trypanosoma brucei brucei were exposed to exogenous putrescine for 24 h during in vitro culture, the rate of O2 consumption increased significantly in a concentration-related and time-dependent manner. Trypanosomes cultured with 100 microM DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine ...
B F, Giffin, P P, McCann, C J, Bacchi
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A successful backcross in Trypanosoma brucei
Molecular and Biochemical Parasitology, 1995Genetic exchange can take place between different strains of Trypanosoma brucei ssp. when they are cotransmitted via the tsetse fly vector, but the mechanism and limits of compatibility between strains are ill-defined as yet. Following the recovery of several hybrid genotypes with single drug resistance from a cross of drug resistant parental strains ...
W, Gibson, G, Kanmogne, M, Bailey
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Stable transformation of Trypanosoma brucei
Molecular and Biochemical Parasitology, 1993We have further analyzed parameters affecting stable transformation of Trypanosoma brucei. Linear DNA was much more efficient than circular DNA and in the vast majority of transformants analyzed the plasmid DNA had inserted into the chromosomes by homologous recombination.
ten Asbroek, A. L. +3 more
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cAMP signalling in Trypanosoma brucei
International Journal for Parasitology, 2001Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host ...
Seebeck T +5 more
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Enzymatic Targets in Trypanosoma brucei
Current Protein & Peptide Science, 2016One of the most neglected disease is the Sleeping sickness or Human African Trypanosomiasis (HAT), which is mostly restricted to poor regions of Africa. The disease is caused by parasitic infection with Trypanosoma brucei (T. brucei), and is acquired through the bite of the tsetse fly.
Luciana, Scotti +3 more
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Self-fertilisation in Trypanosoma brucei
Molecular and Biochemical Parasitology, 1996We have investigated whether Trypanosoma brucei can undergo self-fertilisation. A group of 27 metacyclic clones derived from the tsetse transmission of a mixture of two genetically marked stocks was analysed and 22 clones were observed to be of non-hybrid phenotype.
A, Tait +3 more
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Glycolysis in Trypanosoma brucei
European Journal of Biochemistry, 1980The possibility that the glycosomes present in the bloodstream form of Trypanosoma brucei [Opperdoes, F. R. and Borst, P. (1977) FEBS Lett. 80, 360–364] constitute a separate pool of glycolytic intermediates within the cell was investigated.In titrations of intact cells with digitonin, a differential activation of glycolytic enzymes was observed ...
N, Visser, F R, Opperdoes
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The Cytoskeletal Architecture of Trypanosoma brucei
The Journal of Parasitology, 1991The cytoskeleton of Trypanosoma brucei has been analyzed by the high-resolution technique of quick-freeze deep-etch rotary-shadowing electron microscopy. The study provides detailed structural information on the subpellicular array of microtubules, the flagellum, and the interaction of these 2 major structures of the trypanosomal cytoskeleton with each
A, Hemphill, D, Lawson, T, Seebeck
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Genetic exchange in Trypanosoma brucei
Parasitology Today, 1990The discovery of genetic exchange in African trypanosomes belonging to the Trypanosoma brucei group is an important development in our understanding of these organisms. Genetic exchange is a feature of major importance in relation to population structure and speciation.
A, Tait, C M, Turner
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