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Trypanosoma brucei and the nervous system
Trends in Neurosciences, 1994African sleeping sickness, characterized by a peculiar pain syndrome and prominent neuropsychiatric symptoms, is caused by the parasite Trypanosoma brucei (T.b.). In experimental T.b. infections, a molecule released from the trypanosomes has been isolated that binds to the CD8 molecule of T cells, whereby T cells are activated to secrete interferon ...
Bentivoglio M. +3 more
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Enzymatic Targets in Trypanosoma brucei
Current Protein & Peptide Science, 2016One of the most neglected disease is the Sleeping sickness or Human African Trypanosomiasis (HAT), which is mostly restricted to poor regions of Africa. The disease is caused by parasitic infection with Trypanosoma brucei (T. brucei), and is acquired through the bite of the tsetse fly.
Luciana, Scotti +3 more
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Self-fertilisation in Trypanosoma brucei
Molecular and Biochemical Parasitology, 1996We have investigated whether Trypanosoma brucei can undergo self-fertilisation. A group of 27 metacyclic clones derived from the tsetse transmission of a mixture of two genetically marked stocks was analysed and 22 clones were observed to be of non-hybrid phenotype.
A, Tait +3 more
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Glycolysis in Trypanosoma brucei
European Journal of Biochemistry, 1980The possibility that the glycosomes present in the bloodstream form of Trypanosoma brucei [Opperdoes, F. R. and Borst, P. (1977) FEBS Lett. 80, 360–364] constitute a separate pool of glycolytic intermediates within the cell was investigated.In titrations of intact cells with digitonin, a differential activation of glycolytic enzymes was observed ...
N, Visser, F R, Opperdoes
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The Cytoskeletal Architecture of Trypanosoma brucei
The Journal of Parasitology, 1991The cytoskeleton of Trypanosoma brucei has been analyzed by the high-resolution technique of quick-freeze deep-etch rotary-shadowing electron microscopy. The study provides detailed structural information on the subpellicular array of microtubules, the flagellum, and the interaction of these 2 major structures of the trypanosomal cytoskeleton with each
A, Hemphill, D, Lawson, T, Seebeck
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Malleable Mitochondrion of Trypanosoma brucei
2015The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology of an early-branching parasitic protist, Trypanosoma brucei, a causative agent of serious human and cattle diseases.
Zdeněk, Verner +15 more
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Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
Cell Reports, 2021Mariana DE NIZ +2 more
exaly
Uptake of α-difluoromethylornithine by Trypanosoma brucei brucei
Biochemical Pharmacology, 1986A J, Bitonti +3 more
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Protein isoprenylation in Trypanosoma brucei brucei
Biochemical Society Transactions, 1996H, Field +3 more
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