Results 131 to 140 of about 22,398 (184)

Chemical and Genetic Validation of an Essential Calcium Entry Channel of <i>Trypanosoma brucei</i> as a Therapeutic Target. [PDF]

ACS Infect Dis
Huang G, Singh H, Singh P, Varshnaya RK, Hamelberg D, Wang B, Docampo R.   +6 more
europepmc   +1 more source

Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

Banerjee S, Minshall N, Cook AD, Macleod O, Webb H, Higgins M, Carrington M.   +6 more
europepmc   +1 more source

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions

Monti L, Firth G, Faria JRC, Kelly JM, Flint G, Galli S, Maher TE, Di Antonio M.   +7 more
europepmc   +1 more source

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Carnitine in Trypanosoma brucei brucei

Molecular and Biochemical Parasitology, 1982
Abstract Bloodstream and culture forms of Trypanosoma brucei brucei contain high concentrations of intracellular l -carnitine, determined enzymatically (1.46 ± 0.28 and 4.49 ± 0.34 mM , respectively), a large proportion of which is non-esterified.
R A, Klein, J M, Angus, A E, Waterhouse
openaire   +2 more sources

Transketolase in Trypanosoma brucei

Molecular and Biochemical Parasitology, 2011
A single copy gene, encoding a protein highly similar to transketolase from other systems, was identified in the Trypanosoma brucei genome. The gene was expressed in E. coli and the purified protein demonstrated transketolase activity with K(m) values of 0.2mM and 0.8mM respectively for xylulose 5-phosphate and ribose 5-phosphate.
Stoffel, Sabine A., Alibu, Vincent P., Hubert, Jane, Ebikeme, Charles, Portais, Jean-Charles, Bringaud, Frédéric, Schweingruber, M. Ernst, Barrett, Michael P.   +7 more
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The coatomer of Trypanosoma brucei

Molecular and Biochemical Parasitology, 2001
Coatomer is a multisubunit complex involved in trafficking of vesicles between the endoplasmatic reticulum and the Golgi apparatus. From sequence homologies, all seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP, are encoded in the genome of Trypanosoma brucei.
A G, Maier, H, Webb, M, Ding, M, Bremser, M, Carrington, C, Clayton   +5 more
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Transport of methionine in Trypanosoma brucei brucei

Molecular and Biochemical Parasitology, 2000
African trypanosomes live free in the bloodstream and central nervous system of mammalian hosts and also within the midgut of the tsetse fly vectors which transmit them. The parasite plasma membrane represents the interface between both hosts and parasite, and trypanosomes accumulate many essential metabolites via specific transport processes.
M P, Hasne, M P, Barrett
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Biosynthesis of Trypanothione in Trypanosoma brucei brucei

Biological Chemistry, 2003
Trypanothione [T(SH)2], the major redox mediator in pathogenic trypanosomatids, is synthetized stepwise by two distinct enzymes in Crithidia fasciculata, while in Trypanosoma cruzi a single enzyme catalyzes both steps. A full-length reading frame presumed to encode trypanothione synthetase (TryS) was obtained by PCR using DNA of T.
Marcelo, Comini, Ulrich, Menge, Leopold, Flohé   +2 more
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Kinetics of Methionine Transport and Metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Archives of Biochemistry and Biophysics, 2000
Methionine is an essential amino acid for both prokaryotic and eukaryotic organisms; however, little is known concerning its utilization in African trypanosomes, protozoa of the Trypanosoma brucei group. This study explored the Michaelis-Menten kinetic constants for transport and pool formation as well as metabolic utilization of methionine by two ...
B, Goldberg, D, Rattendi, D, Lloyd, N, Yarlett, C J, Bacchi   +4 more
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