Results 31 to 40 of about 54,768 (257)

Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation [PDF]

, 2012
Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the ...
Eva Greganova, Manfred Heller, Michael Altmann, Peter Bütikofer, Sandra Eltschinger, Thomas Preiss   +5 more
core   +17 more sources

P-type transport ATPases in Leishmania and Trypanosoma

Parasite, 2019
P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
doaj   +1 more source

Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary, Nadia M. Lithy, Elham Amin, Sameh F. AbouZid, Rabab Mohammed   +4 more
doaj   +1 more source

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources

Characterization of an endopeptidase of Trypanosoma brucei brucei

Archives of Biochemistry and Biophysics, 1992
A soluble 80-kDa endopeptidase has been isolated from Trypanosoma brucei brucei. The enzyme, which has a pI 5.1, is optimally active at about pH 8.2 and has apparent pKa values of 6.0 and greater than or equal to 10. It is inhibited by the serine protease inhibitor diisopropylfluorophosphate and by the serine protease mechanism-based inhibitor 3,4 ...
Kornblatt, M.J., Mpimbaza, G.W.N., Lonsdale-Eccles, J.D.   +2 more
openaire   +4 more sources

Population genetics of Trypanosoma brucei circulating in Glossina palpalis palpalis and domestic animals of the Fontem sleeping sickness focus of Cameroon

Parasites & Vectors, 2014
Background Human African Trypanosomiasis is still a public health threat in Cameroon. To assess Trypanosoma brucei strains circulating in the Fontem sleeping sickness focus, we conducted a genetic structure study using microsatellites to assess genotypes
Gustave Simo, Guy Roger Njitchouang, Tresor Tito Tanekou Melachio, Flobert Njiokou, Gerard Cuny, Asonganyi Tazoacha   +5 more
doaj   +1 more source

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P., Guisez, Y., Lejon, V., Rogé, S., Van Nieuwenhove, L.   +4 more
core   +1 more source

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three ...
Jean Guillon, Anita Cohen, Clotilde Boudot, Alessandra Valle, Vittoria Milano, Rabindra Nath Das, Aurore Guédin, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Maxime Demourgues, Elodie Reviriego, Sandra Rubio, Sandie Ferriez, Patrice Agnamey, Cécile Pauc, Serge Moukha, Pascale Dozolme, Sophie Da Nascimento, Pierre Laumaillé, Anne Bouchut, Nadine Azas, Jean-Louis Mergny, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux   +25 more
doaj   +1 more source

Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.

PLoS Pathogens, 2021
Human African Trypanosomiasis (HAT) has been responsible for several deadly epidemics throughout the 20th century, but a renewed commitment to disease control has significantly reduced new cases and motivated a target for the elimination of Trypanosoma ...
Alexandre Girard, Anneli Cooper, Samuel Mabbott, Barbara Bradley, Steven Asiala, Lauren Jamieson, Caroline Clucas, Paul Capewell, Francesco Marchesi, Matthew P Gibbins, Franziska Hentzschel, Matthias Marti, Juan F Quintana, Paul Garside, Karen Faulds, Annette MacLeod, Duncan Graham   +16 more
doaj   +1 more source