Results 101 to 110 of about 68,686 (295)
Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria
Parasites & Vectors, 2019 Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana +3 more
doaj +1 more source
, 2011 Artyicle approval pendingHuman African trypanosomiasis (HAT), or sleeping sickness, is a vector-borne disease that flourishes in impoverished, rural parts of sub-Saharan Africa. It is caused by infection with the protozoan parasite Trypanosoma brucei and
Chappuis, F, Malvy, D
core +2 more sources
Cellular Physiology and Biochemistry, 2013 Background: Trypanosoma brucei is a primitive parasitic protozoan that thrives in diverse environments such as the midgut of the tsetse fly and the blood of a mammalian host.
Néstor L. Uzcátegui +6 more
doaj +1 more source
Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]
, 2017 Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara +2 more
core +1 more source
Spatiotemporal Control Over Circadian Rhythms With Light
Medicinal Research Reviews, Volume 45, Issue 3, Page 968-984, May 2025.ABSTRACT Circadian rhythms are endogenous biological oscillators that synchronize internal physiological processes and behaviors with external environmental changes, sustaining homeostasis and health. Disruption of circadian rhythms leads to numerous diseases, including cardiovascular and metabolic diseases, cancer, diabetes, and neurological disorders.
Dušan Kolarski +2 more
wiley +1 more source
Intracellular protein crystallization in living insect cells
FEBS Open Bio, Volume 15, Issue 4, Page 551-562, April 2025.This research protocol provides a step‐by‐step guide for applying the InCellCryst pipeline for intracellular protein crystallization. After gene cloning and generation of recombinant baculoviruses, High Five insect cells are infected for target protein crystallization.
Robert Schönherr +8 more
wiley +1 more source
Microbiology Research, 2017 The plant Pomegranate (Punica granatum Linn.) selected for this study is native to the region of Eurasia. The objective of this study was to evaluate the antitrypanosomal potential of the plant against Trypanosoma brucei brucei (T.b.
Muhammad Muhsin Fathuddin +1 more
doaj +1 more source
Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development
ChemBioChem, Volume 26, Issue 7, April 1, 2025.Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen +8 more
wiley +1 more source
N‐Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii
PROTEOMICS, Volume 25, Issue 8, April 2025.ABSTRACT Protein N‐glycosylation influences protein folding, stability, and trafficking, and has prominent functions in cell–cell adhesion and recognition. For the parasite Toxoplasma gondii, N‐glycosylation of proteins is crucial for initial adhesion to host cells, parasite motility, and consequently, its ability to invade host cells.
Vanessa Horn +5 more
wiley +1 more source
Biochemical Journal, 1999 Here we examine a cell death process induced by reactive oxygen species (ROS) in the haemoflagellate Trypanosoma brucei brucei. Ca2+ distribution in cellular compartments was measured with stable transformants expressing aequorin targeted to the cytosol,
E. L. Ridgley, Z. Xiong, Larry Ruben
semanticscholar +1 more source