Results 121 to 130 of about 69,743 (296)

Ciliary IFT‐B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

Cell Proliferation, Volume 58, Issue 7, July 2025.
Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang, Jing Zhang, Fei Yan, Yihong Chen, Yang Wu, Jiaxin Luo, Lian Duan, Juan Zou, Juncen Guo, Jiyun Pang, Andras Dinnyes, Jiuzhi Zeng, Weixin Liu, Chi Chiu Wang, Yi Lin, Xue Xiao, Xiaomiao Zhao, Wenming Xu   +17 more
wiley   +1 more source

Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]

, 2017
Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara, Kennedy, Peter G.E., Rodgers, Jean   +2 more
core   +1 more source

Trypanosoma brucei infection protects mice against malaria.

PLoS Pathogens, 2019
Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness,
Margarida Sanches-Vaz, Adriana Temporão, Rafael Luis, Helena Nunes-Cabaço, António M Mendes, Sarah Goellner, Tânia Carvalho, Luisa M Figueiredo, Miguel Prudêncio   +8 more
doaj   +1 more source

Response of Trypanosoma brucei brucei-induced anaemia to a commercial herbal preparation

, 2003
®is a herbal preparation made from three medicinal herbs (Parquetina nigrescens, Sorghum bicolor and Harungana madagascariensis). It has been reported to have been successfully used in the treatment of anaemia in humans. A study was therefore carried out
P. Erah, C. Asonye, A. O. Okhamafe
semanticscholar   +1 more source

A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Mice infected with the protozoan parasite Trypanosoma brucei brucei and treated subcuratively with the trypanocidal drug diminazene aceturate develop an acute inflammatory meningoencephalitis with associated astrocytic proliferation.
P. Kennedy, J. Rodgers, F. Jennings, M. Murray, S. Leeman, J. Burke   +5 more
semanticscholar   +1 more source

In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger

Chemistry &Biodiversity, Volume 22, Issue 6, June 2025.
Workflow of current study. ABSTRACT Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
Souleymane Magagi Damé, Louis Leclercq, Catherine Vonthron‐Sénécheau, Amadou Tidjani Ilagouma, Sergio Ortiz   +4 more
wiley   +1 more source

Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.

Biochemical Journal, 1991
We reported recently that administration of ([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL 73811), an enzyme-activated irreversible inhibitor of S-adenosyl-L-methionine decarboxylase (AdoMetDC; EC 4.1.1.50), a key enzyme in the synthesis of ...
T. Byers, T. Bush, P. McCann, A. Bitonti
semanticscholar   +1 more source

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.

, 2002
In most aerobic organisms hemoperoxidases play a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity.
Kelly, John M, Mauricio, Isabel L, Obado, Samson O, Wilkinson, Shane R   +3 more
core   +2 more sources

Performance of diagnostic tests for Trypanosoma brucei brucei in experimentally infected pigs. [PDF]

PLoS Negl Trop Dis, 2023
Ilboudo K, Boulangé A, Hounyèmè RE, Gimonneau G, Kaboré J, Belem AGM, Desquesnes M, Lejon V, Koffi M, Jamonneau V, Thévenon S.   +10 more
europepmc   +1 more source

Consistent detection of Trypanosoma brucei but not T. congolense DNA in faeces of experimentally infected cattle

Scientific Reports
Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT empirical and immunodiagnostic surveillance tools suffer from poor sensitivity and specificity, with blood sampling requiring ...
Isabel Saldanha, Martha Betson, Christina Vrettou, Edith Paxton, James Nixon, Peter Tennant, Adrian Ritchie, Keith R. Matthews, Liam J. Morrison, Stephen J. Torr, Lucas J. Cunningham   +10 more
doaj   +1 more source