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Lipid metabolism in Trypanosoma brucei [PDF]
Molecular and Biochemical Parasitology, 2010 Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid ...
Smith Terry K, Bütikofer Peter
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Resolving Trypanosoma brucei Flagellar Structure by Cryo-Electron Tomography [PDF]
E3S Web of Conferences, 2019 Trypanosoma brucei is a unicellular eukaryote that can cause human African trypanosomiasis, which has continued to evolve and spread. The key feature of these parasites is that they have a flagellum consists of a typical 9 + 2 axoneme and a lattice-like ...
Dai Jennifer
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American Journal of Tropical Medicine and Hygiene, 2009 There is an urgent need for new compounds for the drug development pipeline for treatment of patients with African sleeping sickness. One approach for identifying such compounds is by high throughput screening (HTS) of compound collections.
M. Sykes, V. Avery
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Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
, 2016 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P. +4 more
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Experimental Parasitology, 2001 We have evaluated whether sequence polymorphisms in the rRNA intergenic spacer region can be used to study the relatedness of two subspecies of Trypanosoma brucei. Thirteen T. brucei isolates made up of 6 T. b. brucei and 7 T. b. gambiense were analyzed using restriction fragment length polymorphism (RFLP).
Agbo, E.C. +3 more
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Data in Brief, 2015 Here we describe the isolation and purity determination of Trypanosoma brucei (T. b.) brucei candidate target proteins of artemisinin. The candidate target proteins were detected and purified from their biological source (T. b.
Benetode Konziase
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European Journal of Biochemistry, 1987 The kinetic properties of Trypanosoma brucei brucei triose-phosphate isomerase are compared with those of the commercially available rabbit muscle and yeast enzymes and with published data on the chicken muscle enzyme.
A. Lambeir +2 more
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Golgi-associated phosphohydrolases in Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1997 Various parasitic protozoa of the family Trypanosomatidae such as Crithidia spp. [1]; Trypanosoma cruzi [2]; Leishmania donovani [3] and salivarian trypanosomes [4-8] have been shown to contain acid phosphatase activity (EC.3.1.3.2, orthophosphoric-monoester phosphohydrolase activity).
Grab, D.J. +3 more
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UMYU Journal of Microbiology ResearchStudy’s Novelty/Excerpt • The potential of Hymenocardia acida stem bark extracts as an anti-trypanosomal agent was assessed. • The results indicate significant in vitro activity of both ethanolic and n-hexane extracts against Trypanosoma brucei brucei
Lawal, S. M. +3 more
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The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes
Molecules, 2022 Profiling a propolis sample from Papua New Guinea (PNG) using high-resolution mass spectrometry indicated that it contained several triterpenoids. Further fractionation by column chromatography and medium-pressure liquid chromatography (MPLC) followed by
Samya S. Alenezi +10 more
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