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Annals of Tropical Medicine & Parasitology, 2006
Trypanosomiasis remains one of the most serious constraints to economic development in sub-Saharan Africa and, as a consequence, related research has been subject to strong social and political as well as scientific influences. The epidemics of sleeping sickness that occurred at the turn of the 20th Century focussed research efforts on what became ...
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Trypanosomiasis remains one of the most serious constraints to economic development in sub-Saharan Africa and, as a consequence, related research has been subject to strong social and political as well as scientific influences. The epidemics of sleeping sickness that occurred at the turn of the 20th Century focussed research efforts on what became ...
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Chemotherapy of African trypanosomiasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1976No new effective drugs for trypanosomiasis, human or animal, have been brought into field use for 20 years; increased drug development costs, the generally small drug budgets of developing countries and widespread evolution of drug resistance are primary causes.
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Pathology of African trypanosomiasis
1999African sleeping sickness is characterized by a number of distinct neurological symptoms, which include dysaesthesia, extrapyramidal motor disturbances, disruption of sleep, as well as neuropsychiatric changes including mood disturbances which could represent the initial symptoms (see other chapters in this volume).
Kristensson K. +1 more
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Immunobiology of African Trypanosomiasis
1984African trypanosomes are flagellated Protozoa that include the causative agents of important human and animal diseases (Table I) and are fascinating biologically.
Margaret Pinder, G. E. Roelants
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1994
Publisher Summary This chapter describes African trypanosomes as protozoan parasites that cause disease in humans and livestock. Both Trypanosoma brucei rhodesiense and T. brucei gambiense cause sleeping sickness in humans. Tsetse flies only occur in Africa and Saudi Arabia.
Jan Naessens +4 more
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Publisher Summary This chapter describes African trypanosomes as protozoan parasites that cause disease in humans and livestock. Both Trypanosoma brucei rhodesiense and T. brucei gambiense cause sleeping sickness in humans. Tsetse flies only occur in Africa and Saudi Arabia.
Jan Naessens +4 more
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The Lancet
Human African trypanosomiasis or sleeping sickness is caused by infection with Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense parasites, which are transmitted by tsetse flies in sub-Saharan Africa. Control of human African trypanosomiasis is based on case detection, treatment, and vector control.
Veerle, Lejon +2 more
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Human African trypanosomiasis or sleeping sickness is caused by infection with Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense parasites, which are transmitted by tsetse flies in sub-Saharan Africa. Control of human African trypanosomiasis is based on case detection, treatment, and vector control.
Veerle, Lejon +2 more
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Conflict and human African trypanosomiasis
Social Science & Medicine, 2011Human African Trypanosomiasis (HAT) has reemerged in sub-Saharan Africa as a disease of major public health importance. The success of HAT elimination in sub-Saharan Africa is subject to the feasibility of controlling, eliminating, or mitigating the determinants of incidence in affected countries.
Lea Berrang-Ford +2 more
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2009
Human African trypanosomiasis (HAT) is caused by two subspecies of trypanosomes, Trypanosoma brucei gambiense and T.b. rhodesiense. Clinically, the disease is characterized by an early stage during which patients report non-specifi c symptoms such as fever and malaise, and trypanosomes are found in the blood or in lymph node aspirates.
Honore Meda, Jacques Pépin
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Human African trypanosomiasis (HAT) is caused by two subspecies of trypanosomes, Trypanosoma brucei gambiense and T.b. rhodesiense. Clinically, the disease is characterized by an early stage during which patients report non-specifi c symptoms such as fever and malaise, and trypanosomes are found in the blood or in lymph node aspirates.
Honore Meda, Jacques Pépin
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Chemotherapy of African Trypanosomiasis
2005There is a critical need for new effective chemotherapeutic agents against the African Trypanosomes. At the present time, drug research is primarily focused on the molecular target approach, however, it is suggested that a more balanced approach involving screening against the whole organism be given greater emphasis.
David W. Boykin, John R. Seed
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