Results 51 to 60 of about 34,173 (255)

Management of trypanosomiasis and leishmaniasis [PDF]

British Medical Bulletin, 2012
The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress. For HAT the only advances in treatment over the past two decades have been the introduction of an eflornithine/nifurtimox ...
Barrett, M.P., Croft, S.L.
openaire   +5 more sources

Bioactivity profiles of progressively ring‐fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto‐piperazines as anti‐trypanosome agents.

ChemBioChem, Accepted Article.
A series of all‐cis ring fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4‐fluorophenylalanine and pentafluoroarylphenylalanine were introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G‐protein coupled formylpeptide receptor, FPR2.
David O'Hagan, Mengfan He, Christina M Thomson, Dawn Thompson, Vytautus Kuodis, Terence K. Smith, Sergio Dall'Angelo   +6 more
wiley   +1 more source

Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity

Molecules, 2018
Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature.
Maureen Gumbo, Richard M. Beteck, Tawanda Mandizvo, Ronnett Seldon, Digby F. Warner, Heinrich C. Hoppe, Michelle Isaacs, Dustin Laming, Christina C. Tam, Luisa W. Cheng, Nicole Liu, Kirkwood M. Land, Setshaba D. Khanye   +12 more
doaj   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon

The Pan African Medical Journal, 2011
BACKGROUND: Knowledge about transmission of sleeping sickness in a given focus is of a great importance since it governs the efficacy and the cost-effectiveness of control strategy.
Lisette Kohagne Tongué, Paulette Mengue M’eyi, Raceline Gounoue Kamkuimo, Dramane Kaba, Francis J Louis, Rémy Mimpfoundi   +5 more
doaj   +1 more source

Experimental Trypanosoma evansi infection in donkeys: hematological, biochemical and histopathological changes Infecção experimental em jumentos com Trypanosoma evansi: alterações hematológicas, bioquímicas e histopatológicas

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006
Five adult donkeys were experimentally infected with Brazilian strain of Trypanosoma evansi originally isolated from a naturally infected dog to study the hematological biochemical and histopathological alterations during the evolution of the disease ...
F.A. Cadioli, L.C. Marques, R.Z. Machado, A.C. Alessi, L.P.C.T. Aquino, P A. Barnabé   +5 more
doaj   +1 more source

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

eLife, 2017
Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high ...
Anneli Cooper, H. Ilboudo, V. Alibu, S. Ravel, J. Enyaru, W. Weir, H. Noyes, P. Capewell, M. Camara, J. Milet, V. Jamonneau, Oumou M. Camara, E. Matovu, B. Bucheton, A. MacLeod   +14 more
semanticscholar   +1 more source

Effect of Spiroplasma infection on the mating behavior of Glossina fuscipes fuscipes

Insect Science, EarlyView.
Abstract Tsetse flies are insects of significant public health and zoonotic importance as they are the main vectors of African trypanosomes. To date, an effective vaccine is unavailable and efforts to limit the spread of the disease primarily rely on controlling the tsetse populations.
Giulia Fiorenza, Riccardo Piccinno, Daniel J. Bruzzese, Francesca Scolari, Gloria Milanesi, Claudio Casali, Ludvik M. Gomulski, Francesco Lescai, Federico Forneris, Giuliano Gasperi, Kiswend‐sida M. Dera, Chantel de Beer, Adly M.M. Abd‐Alla, Serap Aksoy, Anna R. Malacrida   +14 more
wiley   +1 more source

Neglected zoonotic diseases in Nigeria: role of the public health veterinarian

The Pan African Medical Journal, 2019
Zoonotic diseases accounts for about 75% of emerging infectious disease and can be devastating to both human and animal health globally. A subset of zoonotic diseases is referred to as "neglected zoonotic diseases - NZDs" as they mainly affect poor ...
Nusirat Elelu, Julius Olaniyi Aiyedun, Ibraheem Ghali Mohammed, Oladapo Oyedeji Oludairo, Ismail Ayoade Odetokun, Kaltume Mamman Mohammed, James Olaniyi Bale, Saka Nuru   +7 more
doaj   +1 more source