Results 71 to 80 of about 32,265 (203)

Generation of neuroinflammation in human African trypanosomiasis

Neurology: Neuroimmunology & Neuroinflammation, 2019
Human African trypanosomiasis (HAT) is caused by infection due to protozoan parasites of the Trypanosoma genus and is a major fatal disease throughout sub-Saharan Africa.
J. Rodgers, I. Steiner, P. Kennedy
semanticscholar   +1 more source

What Is Your Diagnosis? Blood Smear From a North American Beaver (Castor canadensis)

Veterinary Clinical Pathology, EarlyView.
Lilani Munasinghe, Shanika Kurukulasuriya, Tracy Yuen, Dennilyn Parker, Betty Lockerbie   +4 more
wiley   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

The Long Wait for a New Drug for Human African Trypanosomiasis.

Trends in Parasitology, 2018
Human African trypanosomiasis (HAT) is responsible for around 3000 reported cases each year. Treatments for HAT are expensive and problematic to administer, and available drugs are old and less than ideal, some with high levels of toxicity that result in
C. H. Baker, S. Welburn
semanticscholar   +1 more source

Impact of Environmental and Anthropogenic Factors on Mandrill (Mandrillus sphinx) Occupancy and Habitat Use in Monte Alén National Park, Equatorial Guinea

American Journal of Primatology, Volume 88, Issue 2, February 2026.
Camera trap data showed that mandrills were not found evenly distributed across MANP. Mandrill occupancy decreased when distance to water bodies increased. Whereas, when distance to hunting camps increased, mandrill occupancy decreased. ABSTRACT Understanding the ecological and anthropogenic factors shaping primate distribution is critical for ...
Tania Guzmán‐Santillán, Salvador Mandujano, Edward Wright, David Fernández, Juan‐Cruz Ondo Nze Avomo, Fidel Esono Mba Eyono, Timothy Bray   +6 more
wiley   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis

PLoS Neglected Tropical Diseases, 2018
In 2012, the World Health Organisation (WHO) set out a roadmap for the control, elimination, or eradication of 17 neglected tropical diseases by 2020 [1]. Many were skeptical about the achievability of such goals.
M. Barrett
semanticscholar   +1 more source

Kejadian Penyakit Surra pada Sapi Potong di Kabupaten Barru Provinsi Sulawesi Selatan Tahun 2015-2017

Jurnal Medik Veteriner, 2020
Trypanosomiasis (Surra) merupakan salah satu penyakit yang menjadi kendala dalam pengembangan sapi potong di Kabupaten Barru, Sulawesi Selatan. Penyakit Surra menyebabkan kematian dan kerugian ekonomi yang sangat besar bagi peternak.
Alfiyan Syah, Chaerul Basri, Ardilasunu Wicaksono   +2 more
doaj   +1 more source

Ruthenium‐Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study

ChemistryOpen, Volume 15, Issue 2, February 2026.
Computational roadmap to click‐ready quinones. Quantum chemical analysis reveals how substituents modulate the reactivity of trypanocidal naphthoquinones in Ru‐catalyzed CH alkenylation, guiding the design of sulfonyl‐fluoride scaffolds for next‐generation antiparasitic agents.
Esther R. S. Paz, Cauê P. Souza, Joyce C. De Oliveira, Renata G. Almeida, Chonny Herrera‐Acevedo, Sulaiman Lakoh, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior, Felipe Fantuzzi   +8 more
wiley   +1 more source

Modulation of succinyl‐CoA:3‐ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Trypanosomatids are protozoan parasites that remain a global health challenge due to the limited efficacy, safety, and durability of current treatments. Acetate: succinate CoA transferase (ASCT), together with succinyl‐CoA synthase (SCS), forms the ASCT/SCS cycle that fuels ATP production and generates acetate, a central metabolic intermediate
Kota Mochizuki, Daniel Ken Inaoka, Keisuke Fukuda, Hana Kurasawa, Kenji Iyoda, Uta Nakai, Shigeharu Harada, Emmanuel O. Balogun, Frédéric Bringaud, Michael Boshart, Takaya Sakura, Kenji Hirayama, Kiyoshi Kita, Tomoo Shiba   +13 more
wiley   +1 more source