In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]
Molecules 2020, 25(17), 3822, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv +1 more source
Improving Digestibility of Soy Flour by Reducing Disulfide Bonds with Thioredoxin [PDF]
, 2008 The Kunitz trypsin inhibitor (KTI) and the Bowman−Birk inhibitor (BBI) of trypsin and chymotrypsin contain disulfide bonds. Glycinin, the major storage protein in soybeans also contains disulfide bonds.
Faris, Richard +3 more
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Pharmaceutics, 2021 Kunitz-like trypsin inhibitors are one of the most noteworthy research objects owing to their significance in pharmacological studies, including anticarcinogenic activity, obesity regulation and anticoagulation.
Yuqing Chen +10 more
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Quantifying the influence of conformational uncertainty in biomolecular solvation [PDF]
Multiscale.Model.Simul 13 (2015) 1327-1353, 2014 Biomolecules exhibit conformational fluctuations near equilibrium states, inducing uncertainty in various biological properties in a dynamic way. We have developed a general method to quantify the uncertainty of target properties induced by conformational fluctuations. Using a generalized polynomial chaos (gPC) expansion, we construct a surrogate model
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Weak self-interactions of globular proteins studied by small-angle X-ray scattering and structure-based modeling [PDF]
J. Phys. Chem. B 118, 10111-10119 (2014), 2014 We investigate protein-protein interactions in solution by small-angle X-ray scattering (SAXS) and theoretical modeling. The structure factor for solutions of bovine pancreatic trypsin inhibitor (BPTI), myoglobin (Mb), and intestinal fatty acid-binding protein (IFABP) is determined from SAXS measurements at multiple concentrations, from Monte Carlo ...
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Proteinase inhibitors in Brazilian leguminosae
Memorias do Instituto Oswaldo Cruz, 1991 Serine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting factors.
C. A. M. Sampaio +3 more
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Structure and kinetics of chemically cross-linked protein gels from small-angle X-ray scattering [PDF]
Phys. Chem. Chem. Phys. 16, 4002-4011 (2014), 2013 Glutaraldehyde (GA) reacts with amino groups in proteins, forming intermolecular cross-links that, at sufficiently high protein concentration, can transform a protein solution into a gel. Although GA has been used as a cross-linking reagent for decades, neither the cross-linking chemistry nor the microstructure of the resulting protein gel have been ...
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Expression and functional analysis of rat P23, a gut hormone-inducible isoform of trypsin, reveals its resistance to proteinaceous trypsin inhibitors [PDF]
, 2002 Rat P23 is an isoform of trypsin (ogens) synthesized by rat acinar cells. Expression of P23 is stimulated strongly by caerulein, an analogue of cholecystokinin (CCK).
Fukuoka, Shin-Ichi +1 more
core +1 more source
Urinary trypsin inhibitor attenuates lipopolysaccharide-induced neutrophil activation [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundUrinary trypsin inhibitor (UTI), which is speculated to have anti-inflammatory effects, is one of serine protease inhibitors found in human urine and blood. The present study was conducted to clarify the effect of urinary trypsin inhibitor (UTI)
Seong-Heon Lee +5 more
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Effects of sister-line cross on grain yield increase per soybean line plant with plant with various trypsin inhibitor activity in grain [PDF]
Selekcija i Semenarstvo, 2000 In order to develop the initial population the adapted variety Kador and the variety Kunitz were crossed within the soybean breeding program for reduced trypsin inhibitor activity.
Srebrić Mirjana
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