Results 51 to 60 of about 14,721 (198)

Comparison of the diagnostic performance of tryptase and histamine for perioperative anaphylaxis: A multicenter prospective study

Allergology International
Background: Diagnosing perioperative anaphylaxis (POA) is often challenging. Although a guideline recommends measuring tryptase rather than histamine, there is little evidence for this.
Takashi Haraguchi, Tatsuo Horiuchi, Tomonori Takazawa, Kazuhiro Nagumo, Masaki Orihara, Shigeru Saito   +5 more
doaj   +1 more source

Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways

Allergy, EarlyView.
Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen, Tessa Kole, Orestes A. Carpaij, Tatiana Karp, Victor Guryev, Alen Faiz, Kian Fan Chung, Pankaj Bhavsar, Ian M. Adcock, Salman Siddiqui, Andy Lan, Katie L. Raby, Nazanin Zounemat‐Kermani, Chris Brightling, Dave Singh, Janwillem Kocks, Monica Kraft, Bianca Beghé, Klaus F. Rabe, Alberto Papi, Machteld N. Hylkema, Martijn C. Nawijn, Maarten van den Berge   +22 more
wiley   +1 more source

Extending the role of tryptase in perioperative anaphylaxis: Predicting positive results in basophil activation tests

Journal of Allergy and Clinical Immunology: Global
Background: Basophil activation tests (BATs) are useful in identifying culprits of perioperative anaphylaxis (PA), but their utility remains limited due to technical limitations, cost, and availability.
Hugo W.F. Mak, MBBS, MRes[Med], Elaine Y.L. Au, FRCPA, Maegan H.Y. Yeung, MBBS, Valerie Chiang, MBBS, Ki Lam, FRCPA, Jane C.Y. Wong, FHKCP, Heather H.F. Yeung, MSc, Eric Y.T. Chan, FRCPath, Chak-sing Lau, MD, FRCP, Philip H. Li, MD, FRCP   +9 more
doaj   +1 more source

Estimating the within‐subject (CVI) and between‐subject (CVG) biological variation of serum tryptase

Immunity, Inflammation and Disease, 2022
Background Tryptase is used as a biomarker to support the diagnosis of anaphylaxis and hematologic diseases. In the event of a mast cell activation during anaphylaxis, a temporary increase in the concentration of tryptase may be seen.
Birthe R. Skarbø, Erik W. Vinnes, Tore Wentzel‐Larsen, Marit S. Sylte, Torunn O. Apelseth   +4 more
doaj   +1 more source

Tryptase: Genetic and functional considerations

Allergologia et Immunopathologia, 2012
Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes. Four genes are known to encode for these enzymes, with different alleles that give rise to different types of tryptases.
Hern?ndez Hern?ndez, Laura, Sanz Lozano, Catalina Sof?a, Garc?a Solaesa, Virginia, Padr?n, J, Garc?a S?nchez, Mar?a Asunci?n, D?vila Gonz?lez, Ignacio Jes?s, Isidoro Garc?a, Mar?a, Lorente Toledano, F?lix   +7 more
openaire   +3 more sources

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

The release of tryptase from mast cells promote tumor cell metastasis via exosomes

BMC Cancer, 2019
Background Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. Method Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of
Hui Xiao, Mudan He, Guogang Xie, Yanan Liu, Yuxia Zhao, Xiong Ye, Xingjing Li, Min Zhang   +7 more
doaj   +1 more source

Tear Tryptase in Vernal Keratoconjunctivitis [PDF]

Archives of Ophthalmology, 2001
To determine the tear level of tryptase (a marker of mast cell activation) in vernal keratoconjunctivitis (VKC) before and after treatment. In addition, eosinophil counts in conjunctival scrapings and ocular surface temperature before and after treatment were studied.A total of 20 patients, 7 years or older with VKC, were included in this study.
openaire   +2 more sources

Expression of mast cell tryptase and immunoglobulin E is increased in cutaneous photodamage: implications for carcinogenesis

Journal of Dermatological Treatment
Purpose: Mast cells, their serine proteinase tryptase, and immunoglobulin E (IgE) can be involved in cutaneous carcinogenesis.Materials and methods: To study the association of tryptase+ and IgE+ cells with photodamage and skin cancers 385 adult patients
Jenni Korhonen, Hanna Siiskonen, Salla Haimakainen, Rauno J. Harvima, Ilkka T. Harvima   +4 more
doaj   +1 more source

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2

Cell Communication and Signaling, 2018
Background Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-going remodeling processes.
Mariam Bagher, Anna-Karin Larsson-Callerfelt, Oskar Rosmark, Oskar Hallgren, Leif Bjermer, Gunilla Westergren-Thorsson   +5 more
doaj   +1 more source