Results 151 to 160 of about 270,080 (298)
Advances in Cancer Immunotherapy for Solid Tumors
Advanced Science, EarlyView.Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz +1 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2019 Suparat Wangsuwan, Jitlada Meephansan Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandCorrespondence: Jitlada MeephansanDivision of Dermatology, Chulabhorn International College of ...
Wangsuwan S, Meephansan J
doaj
Isotopic Labelling of Tryptophan and Tryptophan Residues in Polypeptides. [PDF]
Acta Chemica Scandinavica, 1969 Børge Bak +5 more
openaire +3 more sources
Advanced Science, EarlyView.Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee +9 more
wiley +1 more source
Advanced Science, EarlyView.Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang +19 more
wiley +1 more source
ON THE DETERMINATION OF TRYPTOPHANE
Journal of Biological Chemistry, 1947 J D, HAUSCHILDT +2 more
openaire +2 more sources
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring
Advanced Intelligent Discovery, EarlyView.A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira +13 more
wiley +1 more source
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie, EarlyView.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +2 more sources