Results 171 to 180 of about 270,080 (298)

Elucidating therapeutic mechanisms of naringin and phloridzin on ulcerative colitis mice by metabolomics-based comparative analysis. [PDF]

Nat Prod Bioprospect
Yang J, Kang C, Xiao C, Zhang Y, Mai Y, Huang Y, Zhan Y, Liu H, Wang X.   +8 more
europepmc   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity

Angewandte Chemie, EarlyView.
A native ene‐reductase, XenA, was repurposed to catalyze the reverse‐enantioselective desaturation of cyclohexanones. The final variant was obtained through extensive protein engineering, combining PROSS‐guided computational design with mutagenesis and screening.
Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu   +4 more
wiley   +2 more sources

Tryptophan's Journey Through Pregnancy: The Role of Serotonin. [PDF]

Int J Tryptophan Res
Gendrot B, Vaillancourt C, Fouquet G.
europepmc   +1 more source

Dietary Tryptophan Plays a Role as an Anti-Inflammatory Agent in European Seabass (Dicentrarchus labrax) Juveniles during Chronic Inflammation

Where teleost fish are concerned, studies in tryptophan immunomodulation generally point to immunosuppressive properties, thus presenting a potential anti-inflammatory dietary strategy.
Paulo Santos, Marina Machado, Aragão, Cláudia, Diogo Peixoto, Azeredo, Rita, Machado, Marina, Inês Duarte, Duarte, Inês, Cláudia Aragão, Peixoto, Diogo, Rita Azeredo, Benjamín Costas, Costas, Benjamín, Ricardo, Ana, Ana Ricardo   +14 more
core   +1 more source

Rapid Fragment Screening by 19F Steady‐State Free Precession NMR

Angewandte Chemie, EarlyView.
19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša, Sintija Ozola, Kostiantyn P. Melnykov, Yaroslav I. Filatov, Serhiy V. Ryabukhin, Raitis Bobrovs, Dmytro M. Volochnyuk, Kristaps Jaudzems, Rihards Aleksis   +8 more
wiley   +2 more sources

Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC-QoL Study. [PDF]

Int J Tryptophan Res
Ooi SL, Kimble B, Pak BS, Micalos PS, Pak SC.   +4 more
europepmc   +1 more source

DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1

Angewandte Chemie, EarlyView.
Hsf1 undergoes phase separation around target DNA, activating stress‐responsive transcription. DNA binding tunes conformational dynamics of Hsf1DBD, which propagates through large‐scale domain rearrangements involving DBD–IDR interactions to regulate phase separation. This hierarchical framework illustrates how local structural events at the side chain
Soichiro Kawagoe, Hiroyuki Kumeta, Tomohide Saio   +2 more
wiley   +2 more sources

The placental tryptophan pathway across gestation: implications for pregnancy outcomes. [PDF]

Hum Reprod Update
Karahoda R, Walker D, Abad C, Anandam KY, Murthi P, Staud F.   +5 more
europepmc   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources