Results 171 to 180 of about 436,973 (328)

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source

The relation between thiamine, biotin and tryptophan metabolism, studied in the rat [PDF]

, 1955
C. E. Dalgliesh
openalex   +1 more source

MoMtg1 Acts as a Novel Transcriptional Repressor of MoSwi6 During Appressorium‐Mediated Penetration in the Rice Blast Fungus

Advanced Science, EarlyView.
Appressoria are specialized penetration structures for many plant pathogenic fungi, demanding precise cell cycle control. This study unveils MoMtg1 as a transcriptional repressor of MoSwi6, orchestrating MoCYC1 expression during turgor‐driven cell cycle progression to enable appressorium‐mediated penetration. Moreover, a small‐molecule inhibitor ZS1619
Xingyu Wang, Ting Zhang, Qi Li, Chang‐An Ji, Lin Huang, Mingzhi Zhang, Leiyun Yang, Xinyu Liu, Muxing Liu, Gang Li, Zhengguang Zhang, Haifeng Zhang   +11 more
wiley   +1 more source

ON THE DETERMINATION OF TRYPTOPHANE

Journal of Biological Chemistry, 1947
W.B. Wallace, T.L. Isaacs, J.D. Hauschildt   +2 more
openaire   +3 more sources

Dual Hydrophilic‐Hydrophobic Core Architecture in Soy Glycinin Amyloid Fibrils Revealed by Cryo‐EM

Advanced Science, EarlyView.
While high‐resolution structures of animal and microbial amyloids are extensively characterized, the structural principles underlying plant‐derived amyloids remain largely unexplored. The study addresses this fundamental gap in knowledge by determining the first near‐atomic‐resolution cryo‐EM structures of amyloid fibrils derived from soy glycinin ...
Saiya Li, Shuangjian Li, Yijia Cheng, Yapeng Fang, Qin Cao, Yiping Cao   +5 more
wiley   +1 more source

THE EFFECT OF ADRENALECTOMY AND OF CORTISONE ADMINISTRATION ON THE METABOLISM OF l-TRYPTOPHAN

, 1956
F. Christine Brown, Clarence P. Berg
openalex   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

Advanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian, Yonghong Xiong, Junbiao Zhan, Zhikun Lu, Yuxi Zhang, Yan Leng, Qin Huang, Zhongyuan Xia   +7 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of l-tryptophan produced with <i>Escherichia coli</i>CCTCC M 2024517 for all animal species (Anhui Huaheng Biotechnology Co., Ltd.). [PDF]

EFSA J
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Röhe I, Theodoridou K, Anguita M, Innocenti ML, Tarrés-Call J, Bozzi Cionci N.   +20 more
europepmc   +1 more source

Cancer of the Urinary Bladder Induced in Mice with Metabolites of Aromatic Amines and Tryptophan

, 1957
Mark Allen, E. Boyland, C E Dukes, E. S. Horning, J.G. Watson   +4 more
openalex   +1 more source

One‐Pot Encapsulation of Enzymes in a Calcium Carboxylate Metal‐Organic Framework for Improved Buffer Stability

Advanced Science, EarlyView.
A biocompatible, room‐temperature synthesis of Ca2⁺–4,5‐imidazoledicarboxylate MOFs enables in situ encapsulation of diverse enzymes with enhanced stability in phosphate buffer. A machine learning workflow integrating Latin hypercube sampling efficiently navigates the synthesis space, optimizing encapsulation efficiency, retained enzymatic activity ...
Ying Shu, Weibin Liang, Jun Huang
wiley   +1 more source