Results 231 to 240 of about 436,973 (328)

AI‐Driven Predictive Design and Functionalization of Three Dimensional‐Printed PEEK Implants with Tryptophan‐Enriched Alginate Hydrogel for Enhanced Biomimetic Surface Performance

open access: yesAdvanced Intelligent Systems, EarlyView.
This study introduces an AI‐guided strategy to design 3D‐printed PEEK implants functionalized with a tryptophan‐enriched alginate hydrogel (TRYALPEEK). The modification improves hydrophilicity, reduces surface roughness, enhances cytocompatibility, and optimizes stress distribution. The platform offers a promising route for personalized implant design,
Wafa Benaatou   +8 more
wiley   +1 more source

A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells

open access: yesAngewandte Chemie, EarlyView.
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self‐labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a light‐induced conformational change. In living cells, this tunable chemigenetic system enables precise spatiotemporal activation and control of emitter ...
Franziska Walterspiel   +10 more
wiley   +2 more sources

De Novo Variants in PPFIA2 in Individuals With Neurodevelopmental Disorders

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Liprin‐α2, encoded by PPFIA2, belongs to the family of Liprin‐α proteins which constitute major synaptic scaffolds participating in the assembly and maturation of synapses. Heterozygous de novo variants in PPFIA2 were identified by exome or genome sequencing in two unrelated individuals with a neurodevelopmental disorder.
Theresa Brunet   +11 more
wiley   +1 more source

High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly

open access: yesAngewandte Chemie, EarlyView.
A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski   +7 more
wiley   +2 more sources

Special Issue "Tryptophan in Nutrition and Health 3.0". [PDF]

open access: yesInt J Mol Sci
Poeggeler B   +3 more
europepmc   +1 more source

The tryptophanase-tryptophan reaction [PDF]

open access: green, 1946
John W. Baker   +2 more
openalex   +1 more source

Home - About - Disclaimer - Privacy