Results 231 to 240 of about 229,751 (309)

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

EFFECT OF 3-ACETYLPYRIDINE ON PYRIDINE NUCLEOTIDE FORMATION FROM TRYPTOPHAN AND NIACIN

, 1955
Selma Hayman, S. S. Shahinian, John Williams, C. A. Elvehjem   +3 more
openalex   +1 more source

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Metabolic Alterations Associated With Rapidly Progressive Chronic Kidney Disease in Cats. [PDF]

J Vet Intern Med
van Mulders L, Vanden Broecke E, Mortier F, de Paepe E, Vanhaecke L, Daminet S.   +5 more
europepmc   +1 more source

UPLC‐ESI‐QTOF‐MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions.
Ines El Mannoubi, Nuha M. Alghamdi, Seham H. Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N. Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira   +8 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Spectroscopic Characterization of Radical Pair Photochemistry in Nonmigratory Avian Cryptochromes: Magnetic Field Effects in <i>Gg</i>Cry4a. [PDF]

J Am Chem Soc
Gravell J, Murton PDF, Pitcher TL, Henbest KB, Schmidt J, Buffett MM, Moise G, Gehrckens AS, Cubbin DR, Štuhec A, Antill LM, Paré-Labrosse O, Bassetto M, Saberamoli G, Xu J, Langebrake C, Liedvogel M, Schleicher E, Weber S, Bartölke R, Mouritsen H, Hore PJ, Mackenzie SR, Timmel CR.   +23 more
europepmc   +1 more source

2‐oxoglutarate analogue‐based biomolecular tools for exploring structure‐activity relationships in non‐heme iron enzymes

ChemBioChem, Accepted Article.
2‐oxoglutarate (2OG)‐dependent non‐heme iron (NHFe) enzymes constitute a family of enzymes that use 2OG and oxygen to catalyze the hydroxylation of unactivated C(sp3)–H bonds. These enzymes are of biological importance and therapeutic interest due to their role in regulating various cellular processes. Herein, we have rationally designed two classes of
Peter Windsor, Sourav Chatterjee, Anoop Rama Damodaran, Ambika Bhagi-Damodaran   +3 more
wiley   +1 more source

Disturbances in amino acid metabolism in obstructive sleep apnea-hypopnea syndrome: insights from a cross-sectional study. [PDF]

Eur J Med Res
Huang J, Chen L, Zhong Y, Xie H, Chen M, Chen G, Lin Q.   +6 more
europepmc   +1 more source

Poly(ethylene Glycol)‐Based Peptidomimetics (Pegtides) of Antimicrobial Peptides

ChemBioChem, EarlyView.
Polyethylene glycol (PEG) is commonly used to improve the pharmacokinetics and pharmacodynamics of therapeutic candidates by conjugation. Here PEG is exploited for peptidomimetic conversion of antimicrobial peptides (AMPs), as candidate antibacterial agents, by replacing their polyamide backbone. The pegtides obtained thereby can be readily synthesized
Conor Shine, John R. F. B. Connolly, Robert D. Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P. Buijs, Hawraa Shahrour, Nathaniel I. Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald‐Hughes, Marc Devocelle   +13 more
wiley   +1 more source