Results 201 to 210 of about 10,379 (248)

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Tryptophan Metabolism in Rabbits

, 2003
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway were studied in male New Zealand white rabbits. Activities are expressed both as specific activity and per g of fresh tissue. Liver tryptophan 2,3-dioxygenase activity (TDO), when assayed in either the absence (holoenzyme) or presence of added haematin (apoenzyme), did not
ALLEGRI, GRAZIELLA, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, BIASIOLO M, COSTA, CARLO VIRGILIO LUIGI   +4 more
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Tryptophan metabolism in health and disease

Cell Metabolism, 2023
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Qingmiao Shi, Yuanshuai Su, Zhengyi Bao   +2 more
exaly   +3 more sources

Tryptophan Metabolism as a Pharmacological Target

Trends in Pharmacological Sciences, 2021
International audienceL-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action
Nathalie Rolhion, Sridhar Mani, Harry Sokol   +2 more
exaly   +2 more sources

Tryptophan Metabolism in Phenylketonurics

JAMA, 1961
ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown. Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain ...
F A, REICHLE, R C, BALDRIDGE, J, DOBBS, M, TROMPETTER   +3 more
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Tryptophan metabolism

Trends in Molecular Medicine, 2013
Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T., Nollen, Ellen A. A.   +1 more
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Tryptophan Metabolism in Atherosclerosis and Diabetes

Current Medicinal Chemistry, 2022
: The essential amino acid tryptophan (Trp) undergoes catabolism through several pathways, producing biologically active metabolites that significantly impact physiological processes. The metabolic pathway responsible for the majority of Trp catabolism is the kynurenine synthesis pathway (KP).
Sudar-Milovanović, Emina, Gluvić, Zoran, Obradović, Milan M., Zarić, Božidarka, Isenović, Esma R.   +4 more
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Free Tryptophan in Plasma and Brain Tryptophan Metabolism

Nature, 1972
SYNTHESIS in the brain of the putative transmitter 5-hydroxytryptamine (5HT) is influenced by the concentration of tryptophan; the rate limiting step in 5HT synthesis is the hydroxylation of tryptophan1 by tryptophan hydroxylase, which is normally unsaturated with substrate2.
P J, Knott, G, Curzon
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Tryptophan Metabolism in Affective Psychoses

British Journal of Psychiatry, 1966
Tryptophan has attracted attention during recent years for the possible role played by some of its metabolites in the aetiology and treatment of psychiatric disorders. Of these metabolites, serotonin has received special attention and considerable work has been carried out in order to elucidate its physiological and pharmacological actions.
C L, Cazzullo, A, Mangoni, G, Mascherpa
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The Control of Tryptophan Metabolism

1975
This volume as a whole describes enzyme induction mechanisms and the influences of enzyme induction upon metabolism and its control. The present chapter deals with various ways in which the metabolism of a single amino acid tryptophan is controlled. While processes influencing this include induction, the de novo synthesis of enzymes which metabolize ...
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