Results 191 to 200 of about 1,087,731 (295)

Targeting tryptophan metabolism in breast cancer immunotherapy: Recent advances and future prospects. [PDF]

Transl Oncol
Li G, Zhou H, Shen X, Ying P, Lu H.
europepmc   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

The gut microbiota-tryptophan metabolism-immune axis in inflammatory bowel disease: Mechanisms and therapeutic prospects. [PDF]

Hum Vaccin Immunother
Wang T, Wang X, Yuan W.
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Forage chemical composition drives early metabolic shifts in ponies fed different haylages

Equine Veterinary Journal, EarlyView.
Abstract Background Rapid changes between feeds can cause dysbiosis and colic in horses. The metabolic consequences of transitioning between haylages (HY) are currently unknown. Objectives To characterise urinary and faecal metabonomics in ponies transitioned between HY varying in botanical composition and physiological age and to evaluate the speed of
M. J. S. Moore‐Colyer, S. Daniels, P. Harris   +2 more
wiley   +1 more source

pH regulates gut bacterial tryptophan metabolism. [PDF]

NPJ Biofilms Microbiomes
Brinck JE, Laursen MF, Pedersen M, Carey MR, Procházková N, Jørgensen MS, Mortensen MS, Lauritzen L, Pedersen O, Roager HM, Licht TR, Sinha AK.   +11 more
europepmc   +1 more source

TRYPTOPHANE METABOLISM

Journal of Biological Chemistry, 1931
openaire   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

Effects of Ellagic Acid on Gut Microbiota and Tryptophan Metabolism in Paraquat-Challenged Piglets Subjected to Ampicillin-Induced Microbiota Perturbation. [PDF]

Antioxidants (Basel)
Deng Y, Wang C, Meng Y, Yin Y, Wang J, Ye Q.   +5 more
europepmc   +1 more source