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Tryptophan Metabolism in Rabbits
2003Enzyme activities involved in tryptophan metabolism along the kynurenine pathway were studied in male New Zealand white rabbits. Activities are expressed both as specific activity and per g of fresh tissue. Liver tryptophan 2,3-dioxygenase activity (TDO), when assayed in either the absence (holoenzyme) or presence of added haematin (apoenzyme), did not
ALLEGRI, GRAZIELLA +4 more
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Trends in Molecular Medicine, 2013
Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T. +1 more
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Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T. +1 more
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Tryptophan Metabolism in Phenylketonurics
JAMA, 1961ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown. Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain ...
F A, REICHLE +3 more
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Tryptophan and serotonin metabolism after sustained tryptophan infusion
Neurochemistry International, 1984In an attempt to elucidate the effects of sustained administration of tryptophan on serotonin synthesis and turnover in mammalian brain, mini-osmotic pumps containing tryptophan or vehicle were implanted in albino mice for 24 and 96 h. Despite the extremely low dose of tryptophan administered by these pumps (8-12 mg/kg-day) statistically significant ...
Peters, Ralph I., Buhr, Bruce R.
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L-tryptophan metabolism in phenylketonuria
The Journal of Pediatrics, 1966A disturbance of the intestinal transport of L-tryptophan and L-tyrosine secondary to the high blood phenylalanine content has been suggested. The L-tryptophan metabolic abnormalities observed in untreated phenylketonuria appear to be due to a transport defect of this amino acid.
M T, Yarbro, J A, Anderson
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Archives of Dermatology, 1967
A young girl with scleroderma and 21 members of her family were studied for their ability to metabolize tryptophan by the pathway which leads to nicotinic acid. Nine of ten female members of the family and two of 12 males had abnormal tryptophan metabolism.
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A young girl with scleroderma and 21 members of her family were studied for their ability to metabolize tryptophan by the pathway which leads to nicotinic acid. Nine of ten female members of the family and two of 12 males had abnormal tryptophan metabolism.
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Tryptophan Metabolism in Affective Psychoses
British Journal of Psychiatry, 1966Tryptophan has attracted attention during recent years for the possible role played by some of its metabolites in the aetiology and treatment of psychiatric disorders. Of these metabolites, serotonin has received special attention and considerable work has been carried out in order to elucidate its physiological and pharmacological actions.
C L, Cazzullo, A, Mangoni, G, Mascherpa
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Tryptophan metabolism in depressive illness
Psychological Medicine, 1974SYSNOPSIS[Methylene-14C]-L-tryptophan was administered intravenously to five patients suffering from severe depression before and after clinical recovery, and to six control subjects; all subjects were tested while on a standard diet. [14C]-5-Hydroxyindoleacetic acid and [14C]-indoleacetic acid were isolated from urine during the following 48 hours and
A, Coppen +4 more
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Tryptophan metabolism in acrodermatitis enteropathica
The Journal of Pediatrics, 1973Tryptophan-loading tests were performed on two normal subjects before and after diiodohydroxyquin treatment and on three acrodermatitis enteropathica patients being treated with diiodohydroxyquin. Patients who received a loading dose of tryptophan had higher urinary levels of kynurenine, kynurenic acid, and acetylkynurenine in comparison with normal ...
A F, Robertson +3 more
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Tryptophan metabolism in experimental porphyria
Biochemical Pharmacology, 1967Abstract Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l -tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l -kynurenine and 3-OH-kynurenine.
A F, Garcia, M, Grinstein
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