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Tryptophan Metabolism in Phenylketonurics
JAMA, 1961ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown. Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain ...
F A, REICHLE +3 more
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Trends in Molecular Medicine, 2013
Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T. +1 more
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Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan.
van der Goot, Annemieke T. +1 more
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Tryptophan Metabolism in Atherosclerosis and Diabetes
Current Medicinal Chemistry, 2022: The essential amino acid tryptophan (Trp) undergoes catabolism through several pathways, producing biologically active metabolites that significantly impact physiological processes. The metabolic pathway responsible for the majority of Trp catabolism is the kynurenine synthesis pathway (KP).
Sudar-Milovanović, Emina +4 more
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Free Tryptophan in Plasma and Brain Tryptophan Metabolism
Nature, 1972SYNTHESIS in the brain of the putative transmitter 5-hydroxytryptamine (5HT) is influenced by the concentration of tryptophan; the rate limiting step in 5HT synthesis is the hydroxylation of tryptophan1 by tryptophan hydroxylase, which is normally unsaturated with substrate2.
P J, Knott, G, Curzon
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Tryptophan Metabolism in Affective Psychoses
British Journal of Psychiatry, 1966Tryptophan has attracted attention during recent years for the possible role played by some of its metabolites in the aetiology and treatment of psychiatric disorders. Of these metabolites, serotonin has received special attention and considerable work has been carried out in order to elucidate its physiological and pharmacological actions.
C L, Cazzullo, A, Mangoni, G, Mascherpa
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The Control of Tryptophan Metabolism
1975This volume as a whole describes enzyme induction mechanisms and the influences of enzyme induction upon metabolism and its control. The present chapter deals with various ways in which the metabolism of a single amino acid tryptophan is controlled. While processes influencing this include induction, the de novo synthesis of enzymes which metabolize ...
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Tryptophan metabolism in depressive illness
Psychological Medicine, 1974SYSNOPSIS[Methylene-14C]-L-tryptophan was administered intravenously to five patients suffering from severe depression before and after clinical recovery, and to six control subjects; all subjects were tested while on a standard diet. [14C]-5-Hydroxyindoleacetic acid and [14C]-indoleacetic acid were isolated from urine during the following 48 hours and
A, Coppen +4 more
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Archives of Dermatology, 1967
A young girl with scleroderma and 21 members of her family were studied for their ability to metabolize tryptophan by the pathway which leads to nicotinic acid. Nine of ten female members of the family and two of 12 males had abnormal tryptophan metabolism.
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A young girl with scleroderma and 21 members of her family were studied for their ability to metabolize tryptophan by the pathway which leads to nicotinic acid. Nine of ten female members of the family and two of 12 males had abnormal tryptophan metabolism.
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Screening for defects in tryptophan metabolism
Journal of Chromatography A, 2000We introduced a two-step procedure for the detection of defects in metabolism of tryptophan: (1) HPTLC (described previously) is suitable when starting the investigation, (2) two HPLC methods with isocratic elution and spectrophotometric detection are used at the next step, when pathological findings are to be confirmed and the individual metabolites ...
E, Marklová +2 more
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Tryptophan metabolism in experimental porphyria
Biochemical Pharmacology, 1967Abstract Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l -tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l -kynurenine and 3-OH-kynurenine.
A F, Garcia, M, Grinstein
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