Results 231 to 240 of about 1,036,536 (283)

Serotonin, Kynurenine, and Indole Pathways of Tryptophan Metabolism in Humans in Health and Disease. [PDF]

Nutrients
Holeček M.
europepmc   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment. [PDF]

Clin Transl Med
Luo Y, Li L, Li S, Wang X, He Z, Song F, Qin J, Zhang J, Xu J.   +8 more
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Extracellular ATP drives tryptophan metabolism and aryl hydrocarbon receptor activation to promote cellular senescence. [PDF]

J Biol Chem
Volonte D, Mullett SJ, Gelhaus SL, Galbiati F.   +3 more
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Multi-Omics Analysis Identifies Tryptophan Metabolism and Glycolysis as Potential Pathways Involved in the Protective Effects of Tormentic Acid Against Metabolic Associated Fatty Liver Disease. [PDF]

Pharmacol Res Perspect
Wei Y, Wei D, Lu J, Wei L, Lin W, Wei J, Ma X.   +6 more
europepmc   +1 more source

Metabolomic profile differs between LADA and type 1 diabetes identifying tryptophan metabolism as a pathway involved in the heterogeneity of autoimmune diabetes. [PDF]

Diabetologia
Maddaloni E, Pezzica S, Amendolara R, Sabatini S, Mocciaro G, Sebastiani G, D'Onofrio L, Carli F, Tesi M, Suleiman M, Navarini L, Nigi L, Formichi C, Vomero M, Minerba M, Marchetti P, Dotta F, Buzzetti R, Gastaldelli A.   +18 more
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Tryptophan Metabolism in Rabbits

, 2003
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway were studied in male New Zealand white rabbits. Activities are expressed both as specific activity and per g of fresh tissue. Liver tryptophan 2,3-dioxygenase activity (TDO), when assayed in either the absence (holoenzyme) or presence of added haematin (apoenzyme), did not
ALLEGRI, GRAZIELLA, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, BIASIOLO M, COSTA, CARLO VIRGILIO LUIGI   +4 more
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Tryptophan metabolism in health and disease

Cell Metabolism, 2023
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Qiuxian Zheng, Zhengyi Bao, Yuanshuai Su   +2 more
exaly   +3 more sources

Tryptophan Metabolism as a Pharmacological Target

Trends in Pharmacological Sciences, 2021
International audienceL-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action
Harry Sokol, Nathalie Rolhion, Sridhar Mani   +2 more
exaly   +2 more sources

Tryptophan Metabolism in Phenylketonurics

JAMA, 1961
ALTHOUGH the genetic defect in the hereditary disorder phenylketonuria has been related to the lack of one of the enzymes involved in the hydroxylation of phenylalanine, the cause of the mental retardation remains unknown. Bickel et al. 1 and other workers noted dramatic improvement in intelligence and developmental quotients of certain ...
F A, REICHLE, R C, BALDRIDGE, J, DOBBS, M, TROMPETTER   +3 more
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Free Tryptophan in Plasma and Brain Tryptophan Metabolism

Nature, 1972
SYNTHESIS in the brain of the putative transmitter 5-hydroxytryptamine (5HT) is influenced by the concentration of tryptophan; the rate limiting step in 5HT synthesis is the hydroxylation of tryptophan1 by tryptophan hydroxylase, which is normally unsaturated with substrate2.
P J, Knott, G, Curzon
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