Results 231 to 240 of about 119,637 (295)

Integrated Transcriptomic and Metabolomic Analysis Revealed That Tryptophan Metabolism-Related Metabolites Are Biomarkers of Trastuzumab Resistance. [PDF]

J Clin Lab Anal
Si X, Wu H, Cao Y, Wei B, Wei J, Wang Z, Mao C.   +6 more
europepmc   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Akkermansia muciniphila reduces neuroinflammation and Aβ deposition via tryptophan metabolism in the APP/PS1 mouse model of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Wang B, Pan M, Yang L, Xu J, Ye C, Li Y, Gong Q, Liu C, Li L, Qin J, Ren D, Zhao C, Liang C.   +12 more
europepmc   +1 more source

Gut microbiota‐mediated immune and metabolic dysregulation in coronary artery disease progression and prognosis

iMeta, EarlyView.
The gut microbiota has emerged as a metabolically active endocrine‐like organ with a crucial role in coronary artery disease (CAD), yet its contribution to adverse clinical outcomes remains incompletely understood. In this prospective cohort of 319 participants, we integrated metagenomic and metabolomic profiling with longitudinal follow‐up over a ...
Honghong Liu, Siqin Feng, Lifeng Liang, Muyun Tang, Yifei Wang, Yiyang Wang, Zhiyu Zhang, Haiping Xing, Chenhong Zhang, Ran Tian, Shuyang Zhang   +10 more
wiley   +1 more source

Diabetes-associated modifications in gut microbiota and tryptophan metabolism: implications for macrophage polarization and wound repair in mice. [PDF]

BMC Microbiol
Ni Y, Feng J, Zhang W, Tang M, Wang S, Shi R, Zhou M, Zhao C.   +7 more
europepmc   +1 more source

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Parkinson's disease: an integrative bioinformatics and machine learning analysis reveals tryptophan metabolism-associated gene biomarkers. [PDF]

BMC Neurol
Zhang J, Zheng M, Shi W.
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Metabolomics and metagenomics in mice reveal the role of the gut microbiota in tryptophan metabolism. [PDF]

iScience
Levé M, Manghi P, Bredon M, Lefevre A, Manara S, Armanini F, Emond P, Planchais J, Rolhion N, Segata N, Sokol H.   +10 more
europepmc   +1 more source