Decoding astrocytic tryptophan metabolism in the pathogenesis of epilepsy: evidence from artificial intelligence-driven multi-omics and clinical validation. [PDF]
Front NeurosciWang W, Sun M.
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Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
Identification of potential biomarkers of tryptophan metabolism in Kawasaki disease and exploration of potential mechanisms. [PDF]
Transl PediatrYuan Y +5 more
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Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis. [PDF]
Gut MicrobesJosephson JK +8 more
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Integrated Metabolomic and Transcriptomic Analyses Identify Elevated Tryptophan Metabolism and Altered Sugar Homeostasis Associated with Honeybee Jujube Flower Disease. [PDF]
Biology (Basel)Zhang M +5 more
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Tryptophan Metabolism in Neurodevelopment and Its Implications For Neurodevelopmental Disorders. [PDF]
Mol NeurobiolGiuliano MG, Tognini P.
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Tryptophan Metabolism as a Pharmacological Target
Trends in Pharmacological Sciences, 2021 International audienceL-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action
Harry Sokol +2 more
exaly +2 more sources
Nutrients, 2021 Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of tryptophan to indolic compounds are fundamental for host health; both of which are altered in colon carcinogenesis.
Leigh Greathouse
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