Results 241 to 250 of about 119,637 (295)

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

A Polygonatum-Based Functional Formula Improves Stress-Induced Depressive-like Behaviors via Modulation of Neuroinflammation and Tryptophan Metabolism. [PDF]

Foods
Zhou G, Jiang N, Liu J, Zhang X, Xu Y, Liu X, Xie M.   +6 more
europepmc   +1 more source

Effects of Environmental Pollutants on Tryptophan Metabolism. [PDF]

Toxics
Hu H, Lu X, Wu M, Bai Z, Liu X.
europepmc   +1 more source

Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila. [PDF]

Exp Mol Med
Wu Q, Hu K, Wang Q, Luo T, Hu L, Liu J, Zou D, Hu J, Guo Z.   +8 more
europepmc   +1 more source

Zn⁶⁴ aspartate modulates inflammation, tryptophan metabolism, and pancreatic function in diet-induced obesity. [PDF]

Sci Rep
Temnik M, Gurin S, Magidenko L, Balakin A, Byshovets R, Kalmukova O, Vovk T, Halenova T, Raksha N, Savchuk O.   +9 more
europepmc   +1 more source

Tryptophan Metabolism in Rabbits [PDF]

, 2003
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway were studied in male New Zealand white rabbits. Activities are expressed both as specific activity and per g of fresh tissue. Liver tryptophan 2,3-dioxygenase activity (TDO), when assayed in either the absence (holoenzyme) or presence of added haematin (apoenzyme), did not
ALLEGRI, GRAZIELLA, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, BIASIOLO M, COSTA, CARLO VIRGILIO LUIGI   +4 more
openaire   +4 more sources

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Tryptophan metabolism in health and disease

Cell Metabolism, 2023
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Qiuxian Zheng, Zhengyi Bao
exaly   +3 more sources

Tryptophan Metabolism as a Pharmacological Target [PDF]

Trends in Pharmacological Sciences, 2021
International audienceL-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action
Harry Sokol, Nathalie Rolhion, Sridhar Mani   +2 more
exaly   +2 more sources