Results 41 to 50 of about 1,400,417 (341)

Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis

Nature Communications, 2023
The upstream metabolism of tryptophan has been described as a metabolic node in glioblastoma. Here the authors show that the downstream metabolism of tryptophan, resulting in the accumulation of quinolinate in glioblastoma, contributes to pro-tumorigenic
Pravin Kesarwani, Shiva Kant, Yi Zhao, Antony Prabhu, Katie L. Buelow, C. Ryan Miller, Prakash Chinnaiyan   +6 more
doaj   +1 more source

Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases

Gut, 2022
Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-products are essential to intestinal homeostasis.
C. Michaudel, C. Danne, A. Agus, A. Magniez, A. Aucouturier, M. Spatz, A. Lefèvre, J. Kirchgesner, N. Rolhion, Yazhou Wang, A. Lavelle, Chloé Galbert, G. Da Costa, Maxime Poirier, Alexia Lapière, J. Planchais, P. Nádvorník, Peter Illes, Cyriane Oeuvray, L. Creusot, Marie‐Laure Michel, N. Benech, A. Bourrier, I. Nion‐Larmurier, C. Landman, Mathias L. Richard, P. Emond, P. Seksik, L. Beaugerie, Rafael Rose Arguello, D. Moulin, S. Mani, Z. Dvořák, L. Bermúdez-Humarán, P. Langella, H. Sokol   +35 more
semanticscholar   +1 more source

Disturbed amino acid metabolism in HIV: association with neuropsychiatric symptoms

Frontiers in Psychiatry, 2015
Blood levels of the amino acid phenylalanine, as well as of the tryptophan breakdown product kynurenine, are found to be elevated in human immunodeficiency virus type 1 (HIV-1)-infected patients.
Johanna M Gostner, Kathrin eBecker, Katharina eKurz, Dietmar eFuchs   +3 more
doaj   +1 more source

Tryptophan plays an important role in yeast’s tolerance to isobutanol

Biotechnology for Biofuels, 2021
Background Isobutanol is considered a potential biofuel, thanks to its high-energy content and octane value, limited water solubility, and compatibility with gasoline.
Hsien-Lin Liu, Christine H.-T. Wang, En-Pei Isabel Chiang, Chieh-Chen Huang, Wen-Hsiung Li   +4 more
doaj   +1 more source

Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection

Frontiers in Microbiology, 2021
Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases.
Xiaolei Wang, Smriti Mehra, Deepak Kaushal, Ronald S. Veazey, Huanbin Xu   +4 more
doaj   +1 more source

Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

iScience, 2022
Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation.
Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel   +15 more
doaj   +1 more source

Alterations in tryptophan metabolism and de novo NAD+ biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation

Frontiers in Medicine
BackgroundInflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by
Jeannie Devereaux, Ainsley M. Robinson, Ainsley M. Robinson, Ainsley M. Robinson, Rhian Stavely, Rhian Stavely, Majid Davidson, Narges Dargahi, Ramya Ephraim, Dimitros Kiatos, Vasso Apostolopoulos, Vasso Apostolopoulos, Vasso Apostolopoulos, Kulmira Nurgali, Kulmira Nurgali, Kulmira Nurgali   +15 more
doaj   +1 more source

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas

Nature Cancer, 2021
The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate their strict control by the tumor genotype ...
M. Friedrich, R. Sankowski, L. Bunse, M. Kilian, E. Green, Carina Ramallo Guevara, S. Pusch, Gernot Poschet, K. Sanghvi, M. Hahn, T. Bunse, Philipp Münch, H. Gegner, J. Sonner, Anna von Landenberg, Frederik Cichon, K. Aslan, Tim Trobisch, Lucas Schirmer, Denis Abu-Sammour, T. Kessler, M. Ratliff, D. Schrimpf, F. Sahm, C. Hopf, D. Heiland, O. Schnell, Jürgen Beck, C. Böttcher, Camila Fernández-Zapata, J. Priller, S. Heiland, I. Gutcher, F. Quintana, A. von Deimling, W. Wick, M. Prinz, M. Plattén   +37 more
semanticscholar   +1 more source

Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer

Molecular Cancer
Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway, and the indole pathway.
Jing Yan, Di Chen, Zi Ye, Xuqiang Zhu, Xueyuan Li, Henan Jiao, Mengjiao Duan, Chaoli Zhang, Jingliang Cheng, Lixia Xu, Hongjiang Li, Dongming Yan   +11 more
semanticscholar   +1 more source

Circadian periodicity of tryptophan metabolism [PDF]

Journal of Clinical Investigation, 1968
Rhythmicity of tryptophan metabolism via the kynurenine pathway has been demonstrated in man. Normal subjects given 3 g of tryptophan at 0900 hours excreted almost three times the quantity of kynurenine, kynurenic acid, and xanthurenic acid than did subjects given the same dose at 2100 hours.
M I, Rapoport, W R, Beisel
openaire   +2 more sources