Results 41 to 50 of about 1,375,182 (353)
Metabolites, 2022 The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and therefore is its burden of disease as NALFD is a risk factor for cirrhosis and is associated with other metabolic conditions such as type II diabetes, obesity, dyslipidaemia ...
C. Teunis, M. Nieuwdorp, N. Hanssen
semanticscholar +1 more source
Nature Communications, 2023 The upstream metabolism of tryptophan has been described as a metabolic node in glioblastoma. Here the authors show that the downstream metabolism of tryptophan, resulting in the accumulation of quinolinate in glioblastoma, contributes to pro-tumorigenic
Pravin Kesarwani +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng +6 more
semanticscholar +1 more source
Disturbed amino acid metabolism in HIV: association with neuropsychiatric symptoms
Frontiers in Psychiatry, 2015 Blood levels of the amino acid phenylalanine, as well as of the tryptophan breakdown product kynurenine, are found to be elevated in human immunodeficiency virus type 1 (HIV-1)-infected patients.
Johanna M Gostner +3 more
doaj +1 more source
Tryptophan plays an important role in yeast’s tolerance to isobutanol
Biotechnology for Biofuels, 2021 Background Isobutanol is considered a potential biofuel, thanks to its high-energy content and octane value, limited water solubility, and compatibility with gasoline.
Hsien-Lin Liu +4 more
doaj +1 more source
Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
Frontiers in Microbiology, 2021 Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases.
Xiaolei Wang +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Primary liver cancer is currently the sixth most common cancer and fourth leading cause of cancer-related death globally. The limited therapeutic options and poor prognosis of patients with primary liver cancer highlight the significance of ...
Wen Chen +15 more
semanticscholar +1 more source
Nature MicrobiologyTryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How gut microbial tryptophan metabolism is directed towards indole, associated with chronic kidney disease ...
A. Sinha +8 more
semanticscholar +1 more source
Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas
Nature Cancer, 2021 The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate their strict control by the tumor genotype ...
M. Friedrich +37 more
semanticscholar +1 more source
Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice
iScience, 2022 Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation.
Josephine Brown +15 more
doaj +1 more source