Results 81 to 90 of about 1,437,430 (390)

Exploring the interplay between running exercises, microbial diversity, and tryptophan metabolism along the microbiota-gut-brain axis

Frontiers in Microbiology
The emergent recognition of the gut-brain axis connection has shed light on the role of the microbiota in modulating the gut-brain axis’s functions. Several microbial metabolites, such as serotonin, kynurenine, tryptamine, indole, and their derivatives ...
Alejandra Vazquez-Medina, Nicole Rodriguez-Trujillo, Kiara Ayuso-Rodriguez, Fabiana Marini-Martinez, Roberto Angeli-Morales, Gerardo Caussade-Silvestrini, Filipa Godoy-Vitorino, Nataliya Chorna   +7 more
doaj   +1 more source

Tryptophan Metabolism in Allergic Disorders [PDF]

International Archives of Allergy and Immunology, 2016
Allergic diseases such as asthma and rhinitis, as well the early phase of atopic dermatitis, are characterized by a Th2-skewed immune environment. Th2-type cytokines are upregulated in allergic inflammation, whereas there is downregulation of the Th1-type immune response and related cytokines, such as interferon-γ (IFN-γ).
Johanna M. Gostner, Barbara Strasser, K. Becker, Dietmar Fuchs, Heinz Kofler   +4 more
openaire   +3 more sources

The Use of Dietary Additives in Fish Stress Mitigation: Comparative Endocrine and Physiological Responses [PDF]

, 2019
In the last years, studies on stress attenuation in fish have progressively grown. This is mainly due to the interest of institutions, producers, aquarists and consumers in improving the welfare of farmed fish.
Abdel-Tawwab, Alderman, Alves Martins, Alves Martins, Alves Martins, Aragão, Araújo, Azeredo, Azeredo, Babaei, Baltzegar, Basic, Basic, Belo, Benítez-Dorta, Berntssen, Berntssen, Betancor, Blazer, Brake, Bransden, Cabanillas-Gámez, Cardoso, Chen, Chen, Chen, Cheng, Conceição, Conde-Sieira, Cosgrove, Costas, Costas, Costas, Costas, Costas, Costas, Dabrowska, Dabrowski, Davis, Dhabhar, Dimitroglou, Doyon, Eissa, Fabbri, Falahatkar, Faught, Fletcher, Forsatkar, Fracalossi, Fu, Fuchs, Ganga, Ganga, Ganga, Gil, González-Silvera, Gorissen, Gorissen, Gorissen, Gorissen, Grimble, Grimble, Guimarães, Habte-Tsion, Halver, Harpaz, Herrera, Hog¨lund, Hooley, Hoseini, Hoseini, Hoseinifar, Hseu, Hwang, Höglund, Höglund, Imanpoor, Iwama, Izquierdo, Jia, Kanazawa, Kenari, Khassaf, Kiilerich, Kim, Kim, Kiron, Kitabchi, Koshio, Koven, Kumar, Kumar, Küçükbay, Lall, Lanes, Leonardi, Leong, Lepage, Lepage, Lepage, Li, Li, Li, Li, Liu, Liu, Liu, Liu, Lochmann, Long, Martin, Martins, Martins, McDowell, McKenzie, McKenzie, Mechlaoui, Melnyk-Lamont, Miao, Mommsen, Montero, Montero, Montero, Montero, Montero, Morandini, Morrow, Naderi, Nye, Olmos-Soto, Palermo, Papoutsoglou, Pardue, Pérez-Jiménez, Pérez-Sánchez, Read, Rezek, Rider, Ringø, Rønnestad, Sakai, Saleh, Sang, Schreck, Schreck, Skrzynska, Solano, Sándor, Tahmasebi-Kohyani, Tejpal, Thompson, Tian, Tocher, Torrecillas, Torrecillas, Trenzado, Trenzado, Trushenski, Van Anholt, Van Anholt, Verburg-van Kemenade, Vijayan, Wang, Watanabe, Weirich, Winberg, Wolkers, Wu, Xie, Xu, Yao, Yoshizawa, Yousefi, Zacharieva   +173 more
core   +2 more sources

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source

Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

Frontiers in Immunology, 2015
The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes ...
Michael ePlatten, Nikolaus evon Knebel Doeberitz, Iris eOezen, Wolfgang eWick, Katharina eOchs   +4 more
doaj   +1 more source

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source

The effect of 3-indoleacetic acid on the response of Lactobacillus arabinosus 17-5 to nicotinamide [PDF]

, 1949
Lactobacillus arabinosus 17-5 has been widely used as an assay organism for nicotinic acid (NA) since the development of the method by Snell and Wright (1). Although it has been realized that other substances present in tissue extracts may interfere with
Galston, Arthur W., Hand, Margery E.
core  

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells

Advanced Functional Materials, EarlyView.
Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +4 more
wiley   +1 more source

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis

Biology Direct
Background Precision oncology’s implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies.
Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia, Gonghui Li, Lei Gao   +17 more
doaj   +1 more source