Results 101 to 110 of about 31,418 (252)

Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling [PDF]

, 2017
The Na+/Mg2+ exchanger SLC41A1 (A1), a key component of intracellular Mg homeostasis (IMH), is the major cellular Mg2+ efflux system, and its overexpression decreases [Mg2+]intracellular.
Abdulhanan, Nasrin, Aschenbach, Jörg R., Cibulka, Michal, Fröhlich, Nadine, Kolisek, Martin, Mastrototaro, Lucia, Pilchova, Ivana, Racay, Peter, Röntgen, Monika, Sponder, Gerhard   +9 more
core   +1 more source

Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature

Histopathology, EarlyView.
Assessment of twenty testicular AGCTs with two different next‐generation sequencing (NGS) panels reveals differences with ovarian AGCTs, including absence of hotspot FOXL2 variants. Aims Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical–pathological differences with their ovarian counterparts.
Costantino Ricci, Dario de Biase, Thais Maloberti, Agnese Orsatti, Thomas M Ulbright, Muhammad T Idrees, Esther Oliva, Kristine Cornejo, João Lobo, Kvetoslava Michalova, Maria Rosaria Raspollini, Sean R Williamson, Geert JLH van Leenders, Chia‐Sui Kao, Fiona Maclean, Ankur R Sangoi, Adeboye O Osunkoya, Michelangelo Fiorentino, Antonio De Leo, Giovanni Tallini, Andres Martin Acosta   +20 more
wiley   +1 more source

Genotype and Phenotype Analysis of Chinese Children With Tuberous Sclerosis Complex: A Pediatric Cohort Study

Frontiers in Genetics, 2020
Tuberous sclerosis complex (TSC) is a genetic condition characterized by the occurrence of hamartomatous wounds stemming from the dysfunction of the mammalian target of rapamycin (mTOR) pathway.
Yifeng Ding, Ji Wang, Shuizhen Zhou, Yuanfeng Zhou, Linmei Zhang, Lifei Yu, Yi Wang   +6 more
doaj   +1 more source

Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data [PDF]

, 2017
Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC).
Ahn, S., Cha, H.L., Hwang, D., Jun, Y., Jung, H.-J., Jung, J., Kim, J., Kim, M., Kim, Y.A., Lee, S., Shin, J., Suh-Kim, H.   +11 more
core   +2 more sources

TSC1/TSC2 Signaling in Pancreatic β-Cells [PDF]

The Open Endocrinology Journal, 2010
The Tuberous Sclerosis complex (TSC) integrates metabolic and growth signals. Recent data demonstrate that this pathway is a major player in regulation of metabolism and energy balance. In this review, we will focus on the role of TSC in modulation of -cell mass and function.
openaire   +1 more source

Papillary renal cell carcinoma, formerly known as Type 2: a single institutional study addressing histologic and molecular features

Histopathology, EarlyView.
Papillary renal cell carcinoma (pRCC) accounts for 15%–20% of RCC cases and is the second most common histologic subtype of RCC. In contrast to other common RCC subtypes, there continues to be ongoing debate about how to classify RCCs with papillary architecture and eosinophilic cytoplasm, given the heterogeneity of histologic, IHC and molecular ...
Melissa Yuwono Tjota, Jung Woo Kwon, Pankhuri Wanjari, Tatjana Antic   +3 more
wiley   +1 more source

Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

Disease Models & Mechanisms, 2013
SUMMARY Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations – such as
Laura Magri, Manuela Cominelli, Marco Cambiaghi, Marco Cursi, Letizia Leocani, Fabio Minicucci, Pietro Luigi Poliani, Rossella Galli   +7 more
doaj   +1 more source

Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma [PDF]

, 2015
Mesothelioma is diagnosed in approximately 2,500 patients in the United States every year, most often arising in the pleural space, but also occurring as primary peritoneal mesothelioma.
Bueno, Raphael, Chirieac, Lucian R., Guo, Yanan, Kwiatkowski, David J., Malinowska, Izabela A., Pass, Harvey, Wu, Wenhao   +6 more
core   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, EarlyView.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

An Analysis of the Dismal Theorem [PDF]

In a series of papers, Martin Weitzman has proposed a Dismal Theorem. The general idea is that, under limited conditions concerning the structure of uncertainty and preferences, society has an indefinitely large expected loss from high-consequence, low ...
William D. Nordhaus
core   +3 more sources