Results 101 to 110 of about 29,860 (247)
TSC1/TSC2 Signaling in Pancreatic β-Cells [PDF]
The Open Endocrinology Journal, 2010 The Tuberous Sclerosis complex (TSC) integrates metabolic and growth signals. Recent data demonstrate that this pathway is a major player in regulation of metabolism and energy balance. In this review, we will focus on the role of TSC in modulation of -cell mass and function.
Ernesto Bernal-MiIzrachi +4 more
openaire +2 more sources
Cell Reports, 2021 Summary: Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder that often presents with psychiatric conditions, including autism spectrum disorder (ASD).
Katelyn N. Benthall +5 more
doaj
Histopathology, Volume 87, Issue 2, Page 258-269, August 2025.Pathohistological analysis of FDCS revealed a morphological spectrum and led to the identification of the adhesion molecule L1CAM as a novel diagnostic immunomarker for FDCS. Sequencing identified NFKBIA as the most frequently altered gene, of note, exclusively in cases with a predominant epithelioid cytomorphology.
Selina Schelbert +12 more
wiley +1 more source
Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models
Disease Models & Mechanisms, 2013 SUMMARY Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations – such as
Laura Magri +7 more
doaj +1 more source
Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]
, 2018 The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan +6 more
core +2 more sources
Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs
Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.miRNAs play multiple roles in the tumour microenvironment of pancreatic cancer, including angiogenesis, interactions with cancer‐associated fibroblasts, the immune microenvironment, exosome communication, the neural microenvironment and metabolic reprogramming.
Jie Ji +9 more
wiley +1 more source
Biological aspects of mTOR in leukemia [PDF]
, 2018 The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp +5 more
core +1 more source
Developmental Disturbances in Animal Models of Autism Spectrum Disorder
Developmental Neurobiology, Volume 85, Issue 3, July 2025.ABSTRACT Although the early signs of autism spectrum disorder (ASD) are widely studied, the significant ambiguity and heterogeneity in symptoms require the comparison of available models, approaches, and the search for common denominators and key indicators.
Kristof Laszlo +3 more
wiley +1 more source
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar +10 more
wiley +1 more source