Results 111 to 120 of about 37,863 (256)

Establishment of Tsc2-deficient rat embryonic stem cells

International Journal of Oncology, 2015
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by TSC1 or TSC2 mutations. TSC causes the development of tumors in various organs such as the brain, skin, kidney, lung, and heart. The protein complex TSC1/2 has been reported to have an inhibitory function on mammalian target of rapamycin complex 1 (mTORC1).
Yoshitaka, Ito, Haruna, Kawano, Fumio, Kanai, Eri, Nakamura, Norihiro, Tada, Setsuo, Takai, Shigeo, Horie, Hajime, Arai, Toshiyuki, Kobayashi, Okio, Hino   +9 more
openaire   +3 more sources

Papillary renal cell carcinoma, formerly known as Type 2: a single institutional study addressing histologic and molecular features

Histopathology, EarlyView.
Papillary renal cell carcinoma (pRCC) accounts for 15%–20% of RCC cases and is the second most common histologic subtype of RCC. In contrast to other common RCC subtypes, there continues to be ongoing debate about how to classify RCCs with papillary architecture and eosinophilic cytoplasm, given the heterogeneity of histologic, IHC and molecular ...
Melissa Yuwono Tjota, Jung Woo Kwon, Pankhuri Wanjari, Tatjana Antic   +3 more
wiley   +1 more source

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

Disease Models & Mechanisms, 2013
SUMMARY Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC1 or
Seok-Hyung Kim, Marie L. Kowalski, Robert P. Carson, L. Richard Bridges, Kevin C. Ess   +4 more
doaj   +1 more source

Data from Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

, 2023
Esther López-Rivera, Padmini Jayaraman, Falguni Parikh, Michael A. Davies, Sühendan Ekmekçioglu, Sudeh Izadmehr, Denái R. Milton, Jerry E. Chipuk, Elizabeth A. Grimm, Yeriel Estrada, Julio A. Aguirre‐Ghiso, Andrew G. Sikora   +11 more
openalex   +1 more source

Double‐chambered left ventricle in a pediatric patient with tuberous sclerosis complex: A case report

Pediatric Investigation, EarlyView.
Haoxuan Li, Yufei Xie, Qun Wu, Xiaomin Duan, Fangyun Wang, Xin Zhang, Jing Wang   +6 more
wiley   +1 more source

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, EarlyView.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source

Data from Regulation of Microtubule-Dependent Protein Transport by the TSC2/Mammalian Target of Rapamycin Pathway

, 2023
Xiuyun Jiang, Raymond S. Yeung
openalex   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis

Cellular & Molecular Biology Letters
Background Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or angiomyolipomas (AMLs) due to inactive mutations of either TSC1 or TSC2 and consequential mTOR hyperactivation.
Shuyun Zhao, Shuai Hao, Jiasheng Zhou, Xinran Chen, Tianhua Zhang, Zhaolai Qi, Ting Zhang, Sajid Jalal, Chuanxin Zhai, Lu Yin, Yufei Bo, Hongming Teng, Yue Wang, Dongyan Gao, Hongbing Zhang, Lin Huang   +15 more
doaj   +1 more source

TSC2 gene characterization and mechanism of ammonia nitrogen stress inhibiting growth through AMPK/mTOR pathway mediated by TSC2 in Megalobrama amblycephala

Aquaculture Reports
This study was performed to evaluate the role of TSC2 (tuberous sclerosis complex 2) in the regulation of growth inhibition of fish exposed to chronic ammonia nitrogen.
Xiangyang Yuan, Qian Wang, Mengyang Dai, Hengjie Wang, Xinyu Xiong, Liang Pan, Canli Wang   +6 more
doaj   +1 more source