Results 121 to 130 of about 25,279 (224)

Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. [PDF]

, 1996
Timothy C. Burn, Timothy D. Connors, Terence J. Van Raay, William R. Dackowski, John M. Millholland, K. Klinger, Gregory M. Landes   +6 more
openalex   +1 more source

TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts

Aging Cell, Volume 24, Issue 7, July 2025.
TFEB dynamics during oxidative stress‐induced premature senescence. The tBHP treatment undermines GSH‐dependent antioxidant mechanisms, leading to increased ROS production and lysosomal damage. In the stress phase, we observed the concomitant inhibition of Akt along with activation of AMPK, together leading to mTOR inhibition and subsequent ...
Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinato   +8 more
wiley   +1 more source

XML Attenuates Ox‐LDL‐Induced Endothelial Progenitor Cell Senescence via Gria2 and cAMP Pathways

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT In‐stent restenosis (ISR) following percutaneous coronary intervention (PCI) is a critical clinical issue, often arising from endothelial injury and impaired repair mechanisms. Endothelial progenitor cells (EPCs), derived from bone marrow, play a key role in vascular health, but their function diminishes with aging and exposure to oxidised low‐
Jinjian Wu, Guotao Lu, Zhou Luo, Meng Cai, Qiankun He, Jie Su, Jianfeng Liu, Rong Wang, Chunyan Kuang   +8 more
wiley   +1 more source

ApoE Inhibits the Progression of Glioma by Activating Immune Function

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Glioma, marked by a low mutational burden, low immunogenicity, high heterogeneity, and the challenges posed by the blood–brain barrier, continues to be a major hurdle in neuro‐oncology. Current research underscores the necessity for more effective medications and treatment strategies.
Xiao‐fei Liu, Yu‐jie Chang, Min Long, Kai‐qi Huang, Bing Wang, Duo Gong, Jun‐Li Luo, Yong Feng   +7 more
wiley   +1 more source

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth [PDF]

, 2001
Xinsheng Gao, Duojia Pan
openalex   +1 more source

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Cell, 2003
K. Inoki, Tianqing Zhu, K. Guan
semanticscholar   +1 more source

TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study

Genetics in Medicine, 2020
B. Ogorek, L. Hamieh, H. Hulshof, Kathryn D. Lasseter, K. Klonowska, Hugo Kuijf, R. Moavero, C. Hertzberg, B. Weschke, Kate Riney, M. Feucht, T. Scholl, P. Krsek, R. Nabbout, A. Jansen, Barbora Benova, E. Aronica, L. Lagae, P. Curatolo, J. Borkowska, K. Sadowski, D. Domanska-Pakiela, Stef G. Janson, P. Kozłowski, Malgorzata Urbanska, J. Jaworski, S. Jóźwiak, F. Jansen, K. Kotulska, D. Kwiatkowski   +29 more
semanticscholar   +1 more source

Successful Treatment of Growing Renal Angiomyolipomas With Low‐Dose Everolimus in a School‐Aged Child With Tuberous Sclerosis Complex

Nephrology, Volume 30, Issue 7, July 2025.
ABSTRACT Renal angiomyolipomas (AMLs) are a common renal manifestation in tuberous sclerosis complex (TSC), occurring in 50%–85% of cases. Even in asymptomatic individuals, treatment is often initiated based on AML size, with mTOR inhibitors being the primary medical therapy.
Satoshi Senoo, Shoichiro Kanda, Keiichi Takizawa, Hiroshi Terashima, Yuko Kajiho, Yutaka Harita   +5 more
wiley   +1 more source

Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 Neurological Abnormalities

Stem Cell Reports, 2017
Summary: Tuberous sclerosis complex (TSC) is a disease featuring devastating and therapeutically challenging neurological abnormalities. However, there is a lack of specific neural progenitor cell models for TSC.
Yaqin Li, Jiqing Cao, Menglong Chen, Jing Li, Yiming Sun, Yu Zhang, Yuling Zhu, Liang Wang, Cheng Zhang   +8 more
doaj  

Multifocal Micronodular Pneumocyte Hyperplasia and Lymphangioleiomyomatosis in Tuberous Sclerosis with a TSC2 Gene [PDF]

, 2001
Hiroshi Maruyama, Kuniaki Seyama, J Sobajima, Kazumichi Kitamura, Tooru Sobajima, Tomokazu Fukuda, Kaoru Hamada, Masahiro Tsutsumi, Okio Hino, Yoichi Konishi   +9 more
openalex   +1 more source