TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway [PDF]
Allergy, Asthma & Clinical Immunology, 2010 Background Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored.
Nguyen Khoa D +2 more
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A Bispecific Antibody Blocking Both TSLP and IL-4Rα for the Treatment of Allergic Inflammatory Diseases [PDF]
CellsThymic stromal lymphopoietin (TSLP) works synergistically with Th2 cytokines to regulate infection, inflammation, and metabolic homeostasis. However, their aberrant activities lead to the onset and sustaining of many types of allergic inflammatory ...
Mingcan Yu +7 more
doaj +2 more sources
TSLP and asthma: fellow travelers [PDF]
Exploration of Asthma & Allergy, 2023 The incidence of asthma, a heterogeneous inflammatory disease affecting over 300 million people worldwide, continues to increase in developed countries.
David El-Qutob, Antonio Letran
doaj +1 more source
Use of the complex of models of regression for analysis of the factors that determine the severity of bronchial asthma [PDF]
, 2020 Background: According to an International Study of Asthma and Allergies in Childhood (ISAAC), the prevalence of asthma in children of 6-7 years old has increased by 10%, and at the age of 13-14 years by 16% over the last decade.
Kozhyna, Olga S., Pihnastyi, O. M.
core +2 more sources
Journal of Translational Medicine, 2022 Objective To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD). Methods Plasma TSLP levels were tested by Elisa, and its receptors were detected by flow cytometry.
Hui Lu +12 more
doaj +1 more source
SARS-CoV-2-Induced TSLP Is Associated with Duration of Hospital Stay in COVID-19 Patients
Viruses, 2023 Thymic stromal lymphopoietin (TSLP) is an epithelium-derived pro-inflammatory cytokine involved in lung inflammatory responses. Previous studies show conflicting observations in blood TSLP in COVID-19, while none report SARS-CoV-2 inducing TSLP ...
Luke Gerla +12 more
doaj +1 more source
Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]
, 2020 Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung +19 more
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Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]
, 2017 The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Beyaert, Rudi +14 more
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Journal of Immunology Research, 2020 Objectives. Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of
Si-Zhe Li +4 more
doaj +1 more source
Exploration of Immunology, 2023 Aim: Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease. Thymic stromal lymphopoietin (TSLP) is highly expressed in the epidermis of patients with AD and induces T helper 2 (Th2) immune responses and itching.
Masanori Fujii +7 more
doaj +1 more source