Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]
Nature Communications, 2017 The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Kenneth Fa Verstraete +2 more
exaly +5 more sources
A Bispecific Antibody Blocking Both TSLP and IL-4Rα for the Treatment of Allergic Inflammatory Diseases [PDF]
CellsThymic stromal lymphopoietin (TSLP) works synergistically with Th2 cytokines to regulate infection, inflammation, and metabolic homeostasis. However, their aberrant activities lead to the onset and sustaining of many types of allergic inflammatory ...
Mingcan Yu +7 more
doaj +2 more sources
TSLP: contrasting roles in cancer [PDF]
Frontiers in ImmunologyThymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα.
Remo Poto +11 more
doaj +2 more sources
Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses
Allergology International, 2020 TSLP is an epithelial cell-derived cytokine synthesized in response to various stimuli, including protease allergens and microorganisms like viruses and bacteria. Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR)
Saeko Nakajima +2 more
exaly +3 more sources
CpG island demethylation and recruitment of SP1 to the promoter region regulates human thymic stromal lymphopoietin expression [PDF]
EpigeneticsThymic Stromal Lymphopoietin (TSLP), an immunomodulatory cytokine, plays a pivotal role in the development and progression of atopic and allergic diseases.
Krishna Priya Ganti, Milan Surjit
doaj +2 more sources
Thymic stromal lymphopoietin in leukemia: A double-edged sword? [PDF]
Leukemia Research ReportsThymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou +6 more
doaj +2 more sources
TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms
Allergology International, 2012 Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of atopic dermatitis patients, TSLP was subsequently found to be
Toshiro Takai
exaly +3 more sources
TSLP and asthma: fellow travelers [PDF]
Exploration of Asthma & Allergy, 2023 The incidence of asthma, a heterogeneous inflammatory disease affecting over 300 million people worldwide, continues to increase in developed countries.
David El-Qutob, Antonio Letran
doaj +1 more source
Use of the complex of models of regression for analysis of the factors that determine the severity of bronchial asthma [PDF]
, 2020 Background: According to an International Study of Asthma and Allergies in Childhood (ISAAC), the prevalence of asthma in children of 6-7 years old has increased by 10%, and at the age of 13-14 years by 16% over the last decade.
Kozhyna, Olga S., Pihnastyi, O. M.
core +2 more sources
Journal of Translational Medicine, 2022 Objective To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD). Methods Plasma TSLP levels were tested by Elisa, and its receptors were detected by flow cytometry.
Hui Lu +12 more
doaj +1 more source