Results 131 to 140 of about 16,704 (236)

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Allergy, Volume 81, Issue 9, Page 3157-3170, September 2026.
ABSTRACT Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed airflow limitation, and long‐term morbidity, particularly in severe disease. Although biologic therapies have transformed outcomes by reducing exacerbations and systemic corticosteroid exposure, their potential to modify structural airway ...
Sebastiano Gangemi, Sara Manti, Johann Christian Virchow, Giorgio Walter Canonica   +3 more
wiley   +1 more source

Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis

Balkan Medical Journal
Background: Psoriasis is a chronic inflammatory skin disease that has no cure. While the specific cause of psoriasis is unknown, interactions between immune cells and inflammatory cytokines are believed to be important in its pathogenesis. Thymic stromal
Cuihao Song, Jie Sun, Zhenkai Zhao, Xu Zhang, Xiangyu Ding, Xiaoqiang Liang, Jia Bai, Liyuan Xing, Lingling Gong, Chengxin Li, Biwen Lin   +10 more
doaj   +1 more source

Signaltransduktion, spezifische Hemmung und biotechnologische Anwendung des humanen TSLP-Rezeptors [PDF]

, 2014
Zytokine als sezernierte Botenstoffe sind ein wichtiger Teil der Kommunikation zwischen Zellen im Organismus. Durch Bindung von membranständigen Rezeptoren auf ihren Zielzellen induzieren sie Proliferation, Differenzierung und verschiedene ...
Wohlmann, Andreas
core  

Processionary Moth Exposure in Europe: Toxic–Irritant and Immunoglobulin E‐Mediated Endotypes, Diagnosis and Management

Clinical &Experimental Allergy, Volume 56, Issue 9, Page 1017-1030, September 2026.
Most reactions are toxic–irritant, driven by epithelial injury and neuro‐inflammatory activation. IgE‐mediated allergy is less common but may cause immediate systemic reactions. Endotype differentiation guides diagnosis, risk stratification and management.
Prasad Dasari, Josefine Haas, Wolfgang Rohe, Kai Gloyna, Christoph Viebahn, Susann Forkel, Michael Szardenings, Christine Stadelmann, Michael P. Schön, Timo Buhl   +9 more
wiley   +1 more source

Revisiting CD8+ T Cells in Allergy: The Emerging Role of Tc2 Cells

Scandinavian Journal of Immunology, Volume 104, Issue 3, September 2026.
Tc2 CD8+ T cells in Type 2 inflammation: induction, tissue adaptation, metabolic programming, and therapeutic implications. Both naïve CD8+ T cells and pre‐committed Tc1 CD8+ T cells can be directed towards a Tc2 phenotype, characterised by secretion of the Type 2 cytokines IL‐4, IL‐5, IL‐9 and IL‐13, which in turn drive eosinophil recruitment, goblet ...
Sabrina de Souza Ferreira, Christopher Andrew Tibbitt   +1 more
wiley   +1 more source

Structure and interaction of the TSLP-T6 complex.

(A) ELISA experiments determining the binding epitopes of AMG157 and T6 on TSLP. (B) Complex structure of TSLP (shown in aquamarine) and T6 (shown in light blue). The binding interface is depicted in wheat color. (C) Ligplot+ analysis of the interactions
Lei Xu (78676), Zhiwei Sun (153761), Changyuan Yu (3755893), Lida Xu (326852), Jia Hao (444898), Yitong Lv (18264686), He Gong (169894), Xuechao Liu (2015425)   +7 more
core   +1 more source

Oral PHGG ameliorates atopic dermatitis‐like dermatitis with concurrent modulation of colonic IgA and cecal microbiota: implications for the gut–skin axis

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6380-6394, 30 August 2026.
Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza, Hyeonjun Yu, Jonghyun Jeong, Jung Cheul Shin, Woo Jung Kim, Sung‐Kwon Moon, Hoon Kim   +6 more
wiley   +1 more source

TSLP in bacterial skin infection [PDF]

Nature Immunology, 2016
openaire   +2 more sources

Rôle du TSLP dans la lymphopoièse B chez la souris

, 2012
L'hématopoïèse a lieu dans le foie fœtal et la moelle osseuse adulte. IL-7 a un rôle essentiel dans le développement des cellules B. Les cellules B ne se développent pas dans la moelle osseuse de souris IL-7 et seul le 10% de cellules B sont produites ...
CIOCCA, Alice, VIEIRA, Paulo Julio de Miranda, PEREIRA, Pablo   +2 more
core  

Pharmacological Evaluation of TSLP Dependency in Preclinical Asthma Models 2246596

Introduction Asthma is a complex life-threatening disease. Deep phenotyping of preclinical models can reveal disease-driving mechanisms and guide new therapies. Methods
Christopher Plummer, Eric Rimmer, Michael Caniga, Lauriane Galle, Jie Zhang-Hoover, Shuxi Qiao   +5 more
core   +1 more source