Results 11 to 20 of about 22,323 (211)

Targeting TSLP in Asthma

Journal of Asthma and Allergy, 2022
Jane R Parnes,1 Nestor A Molfino,1 Gene Colice,2 Ubaldo Martin,2 Jonathan Corren,3 Andrew Menzies-Gow4 1Amgen, Thousand Oaks, CA, USA; 2AstraZeneca, Gaithersburg, MD, USA; 3University of California, Los Angeles, CA, USA; 4Royal Brompton and Harefield ...
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A   +5 more
doaj   +4 more sources

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling [PDF]

Database, 2014
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an
Huang, Tai-Chung, Palapetta, Shyam Mohan, Pandey, Akhilesh, Prasad, T. S. Keshava, Raju, Rajesh, Sharma, Jyoti, Tyner, Jeffrey W., van Bodegom, Diederik, Weinstock, David M., Yoda, Akinori, Zhong, Jun, Ziegler, Steven F.   +11 more
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A New Itch to Scratch for TSLP [PDF]

Trends in Immunology, 2014
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD.
Turner, Matthew J., Zhou, Baohua
core   +4 more sources

TSLP Expression: Analysis with a ZsGreen TSLP Reporter Mouse [PDF]

The Journal of Immunology, 2015
Abstract Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays a central role in induction of allergic inflammatory responses. Its principal targets have been reported to be dendritic cells and/or CD4 T cells; epithelial cells are a principal source.
Cedric, Dewas, Xi, Chen, Tetsuya, Honda, Ilkka, Junttila, Jay, Linton, Mark C, Udey, Stephen F, Porcella, Daniel E, Sturdevant, Lionel, Feigenbaum, Lily, Koo, Joy, Williams, William E, Paul   +11 more
openaire   +2 more sources

TSLP and TSLP receptors variants are associated with smoking [PDF]

Molecular Genetics & Genomic Medicine, 2019
AbstractBackgroundTo search for new prevention markers for early detection of the diseases caused by tobacco, we aimed to investigate the polymorphisms in TSLP and TSLPRs associated with cigarette smoking in the Saudi population.Materials and methodsSamples were collected from 177 smokers and 126 healthy controls. Three TSLP SNPs [rs3806933, rs2289276,
Abdelhabib Semlali, Mikhlid Almutairi, Arezki Azzi, Narasimha Reddy Parine, Abdullah AlAmri, Saleh Alsulami, Talal Meshal Alumri, Mohammad Saud Alanazi, Mahmoud Rouabhia   +8 more
openaire   +3 more sources

Human TSLP-Educated DCs [PDF]

Cellular & Molecular Immunology, 2008
Thymic stromal lymphopoietin (TSLP), an IL-7-related cytokine, is widely expressed by epithelial cells in many tissues with different biological effects. Human TSLP (hTSLP) has been shown to play an important role in promoting T cell homeostasis, developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic ...
Jiongkun, Wang, Feiyue, Xing
openaire   +2 more sources

Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression [PDF]

Genes, 2021
Colorectal cancer (CRC) is the third most common malignancy and the fourth leading cause of cancer-related mortality worldwide. Inflammation is considered as a critical driver for CRC development and growth. We investigated the association between polymorphisms/expression levels of thymic stromal lymphopoietin (TSLP) /TSLP receptors and CRC risk in ...
Abdelhabib Semlali, Mikhlid H. Almutairi, Abdullah Alamri, Narasimha Reddy Parine, Maha Arafah, Majid A. Almadi, Abdulrahman M. Aljebreen, Othman Alharbi, Nahla Ali Azzam, Riyadh Almutairi, Mohammad Alanazi, Mahmoud Rouabhia   +11 more
openaire   +2 more sources

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]

, 2017
BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz, Andras Schaffer, Arturo P. Saavedra, Cipolat, Fenske, Hengameh Mirzaalian, Jean-Pierre Eliane, Lynn A. Cornelius, Mary Tabacchi, Michael Wallendorf, Raphael Kopan, Salasche, Sara Moradi Tuchayi, Seckin, Shadmehr Demehri, Sindhu Manivasagam, Stockfleth, Trevor J. Cunningham, Warino   +18 more
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Elevated Plasma Thymic Stromal Lymphopoietin After Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2022
BackgroundThymic stromal lymphopoietin (TSLP), a distant paralog of the cytokine IL-7, has been shown to be associated with atherosclerosis. However, the effect of plasma TSLP level after acute myocardial infarction (AMI) remains largely unclear.
Yuhao Zhao, Yeping Zhang, Zongsheng Guo, Zheng Ma, Ye Liu, Chunming Han, Xinchun Yang, Lei Zhao   +7 more
doaj   +1 more source

Virtual screening for inhibitors of the human TSLP:TSLPR interaction [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis.
AA Bogan, AC Braisted, AJ Souers, C Ghirelli, D Sun, DR Hall, G Neudert, G Pérez-Hernández, GM Gauvreau, HH Loeffler, J Corren, J Felix, J Yin, JM Wang, K Lindorff-Larsen, K Verstraete, K Verstraete, L Deng, LS Park, M Guillot-Delost, M Noti, M Piazza Di, MJ Abraham, NS Redhu, O Trott, P Buchwald, P Chames, RL Rich, S Demehri, S Doerr, S Ulrich, SD Levin, SF Ziegler, T Clackson   +33 more
core   +2 more sources