Results 21 to 30 of about 22,323 (211)

The role of epithelial cells in atopy pathogenesis

Бюллетень сибирской медицины, 2019
Aim. The study of the mechanisms of atopic disease formation and a model of immunopathogenesis of the atopic diseases.Methods. Determination of surface lymphocytes receptors in peripheral blood of atopic bronchial asthma and atopic dermatitis patients ...
A. N. Kazimirsky, J. M. Salmasi, G. V. Poryadin, O. A. Svitich, B. G. Bragvadze, A. A. Alekseeva, L. V. Gankovskaya   +6 more
doaj   +1 more source

Interactions of thymic stromal lymphopoietin with interleukin-4 in adaptive immunity during Aspergillus fumigatus keratitis [PDF]

International Journal of Ophthalmology, 2021
AIM: To investigate the potential interactions of thymic stromal lymphopoietin (TSLP) with interleukin-4 (IL-4) in adaptive immunity during fungal keratitis (FK).
Chen Chen, Chen-Yang Dai, Fang Han, Jia-Yin Wu, Lin Sun, Xin-Yi Wu   +5 more
doaj   +1 more source

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. [PDF]

, 2017
The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD).
Cheng, D, Di, H, Erle, DJ, Huo, X, Mo, Y, Shi, H, Xu, Y, Yi, L, Zhang, H, Zhang, K, Zhao, J, Zhen, G, Zou, Y   +12 more
core   +1 more source

Cellular networks controlling Th2 polarization in allergy and immunity [PDF]

, 2012
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam, Hammad, Hamida, Lambrecht, Bart   +2 more
core   +1 more source

Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903‐induced Skin Inflammation [PDF]

Eur J Immunol
Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon ...
González‐Rodríguez M, Salomaa T, Cabalin C, Komulainen T, Hiihtola L, Kummola L, Järvinen T, Junttila I.   +7 more
europepmc   +2 more sources

Human Lung-Resident Macrophages Express and Are Targets of Thymic Stromal Lymphopoietin in the Tumor Microenvironment

Cells, 2021
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine highly expressed by epithelial cells and several innate and adaptive immune cells. TSLP exerts its biological effects by binding to a heterodimeric complex composed of TSLP receptor (TSLPR ...
Mariantonia Braile, Alfonso Fiorelli, Daniela Sorriento, Rosa Maria Di Crescenzo, Maria Rosaria Galdiero, Gianni Marone, Mario Santini, Gilda Varricchi, Stefania Loffredo   +8 more
doaj   +1 more source

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]

, 2014
Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal, Aguado, Al-Shami, Allakhverdi, Angkasekwinai, Arwert, Balkwill, Bas, Björkström, Blais, Boyden, Briot, Bryson, Burnet, Burnet, Cella, Cerwenka, Champsaur, Chan, Chao, Chavanas, Chen, Chen, Cheroutre, Conticello, Coussens, Culig, Dalton, Dearman, Deleuran, Demehri, DePinho, Devey, Di Piazza, Dighe, Dunham, Dunn, Dvorak, Ehrlich, Eisenbarth, Ellyard, Engkilde, Eyerich, Farhadi, Felices, Fort, Fritz, Fujisawa, Fukuyama, Furmanski, Fux, Gause, Gebhardt, Giangreco, Girardi, Girardi, Girardi, Golumbek, Gregory, Groh, Gutierrez, Hallett, Hammad, Hams, Harris, Hayday, Heneghan, Hock, Hueber, Humphreys, Imai, Indra, Jackson, Jameson, Jameson, Jensen-Jarolim, Jerde, Jiang, Jiang, Josephs, Jotwani, Jovanovic, Jovanovic, Jung, Kaplan, Karagiannis, Kim, Komai-Koma, Kool, Kool, Kouzaki, Kuroda, Lebel-Binay, Lee, Lindelof, Lodoen, Ma, Magalhaes, Magalhaes, Marichal, Marichal, Matsuda, Matzinger, McCoy, McWhorter, Meehan, Metz, Mishra, Moghaddam, Monticelli, Nestle, Nigro, Obiri, Oh, Okumura, Olver, Ortiz-Urda, Owyang, Palm, Palm, Park, Pastorelli, Pearce, Pedroza-Gonzalez, Pericle, Profet, Qi, Ramsbottom, Raulet, Reali, Renard, Rittmeyer, Rodolfo, Rosenberg, Rölle, Saenz, Sagiv, Salgame, Salimi, Schmidt, Schmitz, Schneider, Schonthaler, Senovilla, Shankaran, Sharp, Sherman, Shi, Shibuya, Simson, Skinnider, Smyth, Soriani, South, Strid, Strid, Strid, Suárez-Alvarez, Swamy, Takahashi, Takai, Tan, Tang, Thomas, Traidl-Hoffmann, Turchinovich, Ullrich, Van Belle, Van Hemelrijck, Vantourout, Verdino, Vernersson, Vesely, Villarreal, Walley, Walter, Wang, Wen, Wen, Wilson, Witherden, Witherden, Wood, Yanaba, Yin, Yoo, Zaiss, Zaph, Zaph, Ziegler, Zitvogel   +190 more
core   +2 more sources

TSLP and Immune Homeostasis

Allergology International, 2012
In an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of appropriate immune responses to T cells.
Shino Hanabuchi, Norihiko Watanabe, Yong-Jun Liu   +2 more
openaire   +3 more sources

ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.

PLoS ONE, 2014
In the skin lesions of atopic dermatitis (AD), keratinocytes release large quantities of thymic stromal lymphopoietin (TSLP), causing unfavorable inflammation along with skin damage.
Terufumi Kubo, Ryuta Kamekura, Ayako Kumagai, Koji Kawata, Keiji Yamashita, Yukari Mitsuhashi, Takashi Kojima, Kotaro Sugimoto, Akihiro Yoneta, Yasuyuki Sumikawa, Toshiharu Yamashita, Noriyuki Sato, Tetsuo Himi, Shingo Ichimiya   +13 more
doaj   +1 more source

The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]

Childhood Kidney Diseases, 2018
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee, Jae Won Yang, Jin Young Cho, Joo Yup Lee, Eun Kyung Lim, Michael Eisenhut, Dong Yeon Jeong, Johanna Steingroever, Jae Il Shin   +8 more
doaj   +1 more source