Results 81 to 90 of about 22,323 (211)

Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]

, 2017
Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola, Bao, James, Barron, Lauren, Colasanti, Jason, Erwin, Christopher R, Guo, Jun, Warner, Brad W   +6 more
core   +2 more sources

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Fine Particulate matter (PM2.5) is a risk factor for dermatitis by promoting the expression of thymic stromal lymphopoietin (TSLP) in keratinocytes

Indian Journal of Dermatology, 2020
Aim: Common indoor pollutants, as fine particulate matter (PM2.5), can damage people's health and cause skin allergies. However, it remains unknown which common pollutants can lead to allergy, such as, in children atopic dermatitis, and what is the key ...
Fei Li, Yongpin Dong, Chunya Ni, Haidong Kan, Shuxian Yan   +4 more
doaj   +1 more source

Intestinal epithelial cell-intrinsic deletion of Setd7 identifies role for developmental pathways in immunity to helminth infection [PDF]

, 2016
The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems.
Antignano, Frann, Braam, Mitchell J., Burrows, Kyle, Chenery, Alistair L., Oudhoff, Menno J., Perona-Wright, Georgia, Redpath, Stephen A., Zaph, Colby   +7 more
core   +4 more sources

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

CpG island demethylation and recruitment of SP1 to the promoter region regulates human thymic stromal lymphopoietin expression

Epigenetics
Thymic Stromal Lymphopoietin (TSLP), an immunomodulatory cytokine, plays a pivotal role in the development and progression of atopic and allergic diseases.
Krishna Priya Ganti, Milan Surjit
doaj   +1 more source

Directional secretory response of double stranded RNA-induced thymic stromal lymphopoetin (TSLP) and CCL11/eotaxin-1 in human asthmatic airways. [PDF]

PLoS ONE, 2014
BACKGROUND:Thymic stromal lymphoproetin (TSLP) is a cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in asthma.
Gustavo Nino, Shehlanoor Huseni, Geovanny F Perez, Krishna Pancham, Humaira Mubeen, Aleeza Abbasi, Justin Wang, Stephen Eng, Anamaris M Colberg-Poley, Dinesh K Pillai, Mary C Rose   +10 more
doaj   +1 more source

Biomarkers of Disease and Treatment in Murine and Cynomolgus Models of Chronic Asthma [PDF]

, 2012
Background Biomarkers facilitate early detection of disease and measurement of therapeutic efficacy, both at clinical and experimental levels. Recent advances in analytics and disease models allow comprehensive screening for biomarkers in complex ...
Beaumont, Maribel, de Waal Malefyt, Rene, Emson, Claire, Fick, Robert B., Li, Ying, Louten, Jennifer, Malinao, Maria-Christina, Mattson, Jeanine D., McClanahan, Terrill K., NC DOCKS at East Carolina University, Van Scott, Michael R., Vega, Felix, Wardle, Robert L.   +12 more
core   +3 more sources

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects [PDF]

, 2012
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine, implicated in the development and progression of allergic diseases.
Claus Bachert, Luo Zhang, Xiaohong Song, Yanming Zhao, Yuan Zhang   +4 more
core   +2 more sources