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Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Chronic lymphocytic leukemia (CLL) is the most common human leukemia. We identified two members of the tRNA-derived small RNA (tsRNA) family, ts-3676 and ts-4521 , both inactivated in CLL and lung cancer.
Giovanni Nigita +2 more
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Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer
Journal of Medical Genetics, 2022Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority sequences in the human genome, and the emergence of high-throughput sequencing technology has greatly expanded our understanding of sncRNAs. sncRNAs are composed of a variety of RNAs, including tRNA-derived small RNA (tsRNA), small nucleolar RNA (snoRNA), small ...
Lin Xiao +4 more
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Transfer- or ‘transmission’-RNA fragments? The roles of tsRNAs in the reproductive system
Molecular Human Reproduction, 2021 ABSTRACTTransfer-RNAs (tRNAs) help ribosomes decode mRNAs and synthesize proteins; however, tRNA fragments produced under certain conditions, known as tRNA-derived small RNAs (tsRNAs), have been found to play important roles in pathophysiological processes. In the reproductive system, tsRNAs are abundant in gametes and embryos and at the maternal–fetal
Honggang Li, Jun Yao, Li Hui-Min
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Gene, 2023
Glioblastomas (GBMs) are the most lethal brain cancer with a median survival rate of fewer than 15 months. Both clinical and biological features of GBMs are largely different from those of low-grade gliomas (LGs), but the reasons for this intratumoral heterogeneity are not entirely clear.
Ming, Tu +6 more
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Glioblastomas (GBMs) are the most lethal brain cancer with a median survival rate of fewer than 15 months. Both clinical and biological features of GBMs are largely different from those of low-grade gliomas (LGs), but the reasons for this intratumoral heterogeneity are not entirely clear.
Ming, Tu +6 more
openaire +2 more sources
Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer
Cancer Letters, 2022tRNA-derived small RNAs (tsRNAs) represent a novel class of regulatory small non-coding RNAs (sncRNAs), produced by the specific cleavage of transfer RNAs (tRNAs). In recent years, pilot studies one after the other have uncovered the critical roles of tsRNAs in various fundamental biological processes as well as in the development of human diseases ...
, Yunlong Lei, Youquan Bu
exaly +3 more sources
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
Frontiers of Medicine, 2022Hepatocellular carcinoma (HCC), which makes up the majority of liver cancer, is induced by the infection of hepatitis B/C virus. Biomarkers are needed to facilitate the early detection of HCC, which is often diagnosed too late for effective therapy. The tRNA-derived small RNAs (tsRNAs) play vital roles in tumorigenesis and are stable in circulation ...
Shoubin, Zhan +10 more
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Gene
Hepatocellular Carcinoma (HCC) is a highly fatal cancer, which is the most common malignant tumor globally. Recently, tRNA-derived small RNA (tsRNA) is a type of non-coding RNA that is closely related to various diseases. However, their precise existence and function in HCC remain unclear.
Xinyue Ma +6 more
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Hepatocellular Carcinoma (HCC) is a highly fatal cancer, which is the most common malignant tumor globally. Recently, tRNA-derived small RNA (tsRNA) is a type of non-coding RNA that is closely related to various diseases. However, their precise existence and function in HCC remain unclear.
Xinyue Ma +6 more
openaire +2 more sources
Advances in research on the mechanism of tsRNA action in tumours
Journal of Medical GeneticstsRNA is a class of non-coding RNAs derived from mature or precursor tRNAs. In recent years, more and more studies have explored the correlation between tsRNAs and tumours. tsRNAs can affect the biological behaviours of tumour cells such as proliferation, apoptosis and metastasis by regulating gene expression, protein translation or post ...
Yan Gao +6 more
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Exploring the Potential of tsRNA as Biomarkers for Diagnosis and Treatment of Neurogenetic Disorders
Molecular NeurobiologytRNA-derived small RNA (tsRNA) is a recently discovered small non-coding RNA (ncRNA) molecule that widely exists in prokaryotic and eukaryotic transcriptomes and is produced by specific cleavage of mature tRNA or precursor tRNA. In recent years, with the development of high-throughput sequencing technology, tsRNA has been found to have a variety of ...
Shiqi, Zhao +4 more
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