Results 1 to 10 of about 8,985 (178)

Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion [PDF]

BMC Biotechnology, 2022
Background Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose role in toxic shock syndrome and ...
Mahdieh Soezi, Somayeh Piri-Gavgani, Mostafa Ghanei, Mir Davood Omrani, Behnoush Soltanmohammadi, Kamran Pooshang Bagheri, Reza Ahangari Cohan, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh, Shohreh Khatami, Masoumeh Azizi, Fatemeh Rahimi-Jamnani   +12 more
doaj   +8 more sources

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1 [PDF]

Toxins, 2017
Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release ...
Thunchanok Rukkawattanakul, Nitat Sookrung, Watee Seesuay, Nattawat Onlamoon, Pornphan Diraphat, Wanpen Chaicumpa, Nitaya Indrawattana   +6 more
doaj   +5 more sources

Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans [PDF]

mSphere, 2021
Atopic dermatitis (eczema, AD) with concurrent herpes simplex virus infection (eczema herpeticum, ADEH) is a severe form of AD.
Patrick M. Schlievert, Richard J. Roller, Samuel H. Kilgore, Miguel Villarreal, Aloysius J. Klingelhutz, Donald Y. M. Leung   +5 more
doaj   +4 more sources

Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus [PDF]

Frontiers in Immunology, 2023
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies.
Stefan Weiss, Stefan Weiss, Silva Holtfreter, Tanja C. Meyer, Frieder Schmiedeke, Clemens Cammann, Marcus Dörr, Marcus Dörr, Stephan B. Felix, Stephan B. Felix, Hans J. Grabe, Georg Homuth, Christian Kohler, Cedric Mahncke, Stephan Michalik, Matthias Nauck, Matthias Nauck, Nele Friedrich, Nele Friedrich, Stefanie Samietz, Henry Völzke, Henry Völzke, Uwe Völker, Uwe Völker, Barbara M. Bröker   +24 more
doaj   +2 more sources

TSST-1⁺Staphylococcus aureus in Bullous Pemphigoid. [PDF]

J Invest Dermatol, 2022
A potential role of Staphylococcus aureus in bullous pemphigoid was explored by examining the colonization rate in patients with new-onset disease compared with that in age- and sex-matched controls. S. aureus colonization was observed in 85% of bullous pemphigoid lesions, 3-6-fold higher than the nares or unaffected skin from the same patients (P ≤ 0 ...
Messingham KN, Cahill MP, Kilgore SH, Munjal A, Schlievert PM, Fairley JA.   +5 more
europepmc   +3 more sources

Toxic Shock Syndrome Toxin-1 (TSST-1) in Staphylococcus aureus: Prevalence, Molecular Mechanisms, and Public Health Implications [PDF]

Toxins
Staphylococcus aureus is a significant pathogen responsible for various infections, with its production of toxic shock syndrome toxin-1 (TSST-1) being a central factor in the pathogenesis of toxic shock syndrome (TSS).
Rahima Touaitia, Nasir Adam Ibrahim, Eman Abdullah Almuqri, Nosiba S. Basher, Takfarinas Idres, Abdelaziz Touati   +5 more
doaj   +2 more sources

Occurrence of Staphylococcus aureus TSST-1 in Foods: A Review [PDF]

Toxins
Toxic Shock Syndrome Toxin-1 (TSST-1) is produced by Staphylococcus aureus strains encoded by the tst gene. Toxic shock syndrome (TSS) is a severe disease caused by TSST-1 toxin and associated with staphylococcal food poisoning (SFP).
Maria Govari, Andreana Pexara
doaj   +2 more sources

TSST-1 promotes colonization of Staphylococcus aureus within the vaginal tract by activation of CD8+ T cells [PDF]

Infection and Immunity
Toxic shock syndrome toxin-1 (TSST-1) is a superantigen produced by Staphylococcus aureus and is the determinant of menstrual toxic shock syndrome (mTSS); however, the impact of TSST-1 on the vaginal environment beyond mTSS is not understood.
Karine Dufresne, Kait F. Al, Heather C. Craig, Charlotte E. M. Coleman, Katherine J. Kasper, Jeremy P. Burton, John K. McCormick   +6 more
doaj   +2 more sources

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4⁺ memory T cells. [PDF]

Commun Biol, 2023
AbstractSevere bacterial or viral infections can induce a state of immune hyperactivation that can culminate in a potentially lethal cytokine storm. The classic example is toxic shock syndrome, a life-threatening complication of Staphylococcus aureus or Streptococcus pyogenes infection, which is driven by potent toxins known as superantigens (SAgs ...
Shepherd FR, Davies K, Miners KL, Llewellyn-Lacey S, Kollnberger S, Redman JE, Grant MM, Ladell K, Price DA, McLaren JE.   +9 more
europepmc   +5 more sources

TSST-1 protein exerts indirect effect on platelet activation and apoptosis

Platelets, 2022
Thrombocytopenia or platelet dysfunction is a risk factor for severe infection. Staphylococcus aureus (S. aureus) releases a variety of virulence factors especially toxic shock syndrome toxin 1 (TSST-1), which may cause toxic shock syndrome. S.
Min Guo, Tiantian Yi, Qian Wang, Daqing Wang, Ping Feng, Dai Kesheng, He Chunyan   +6 more
doaj   +3 more sources