Results 11 to 20 of about 856 (96)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family. [PDF]

Angew Chem Int Ed Engl
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Nißl B, Mülbaier M, Grisoni F, Trauner D, Bermúdez M, Dialer C, Konrad DB.   +6 more
europepmc   +2 more sources

Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning. [PDF]

Adv Sci (Weinh)
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Zhao H, Shi G, Qin R, Sun Y, Guo W, Shi R, Peng M, Yang J, Zhao J, Liu Q, Xiao J, Zhang K, Liu Q, Yang W, Liu H.   +14 more
europepmc   +2 more sources

Environmental factors and host sex influence the skin microbiota structure of Hong Kong newt (Paramesotriton hongkongensis) in a coldspot of chytridiomycosis in subtropical East Asia. [PDF]

Integr Zool
Asymptomatic chytrid fungal infection in the Hong Kong newts suggests their long‐term coexistence with chytrids and a potential protective role of skin microbiota. The skin microbiota of Hong Kong newts has a high prevalence of taxa with putative anti‐fungal properties.
Wan B, Chen G, Poon ESK, Fung HS, Lau A, Sin SYW.   +5 more
europepmc   +2 more sources

New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism

Marine Drugs, 2018
The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with ...
Andrew D. Turner, David Fenwick, Andy Powell, Monika Dhanji-Rapkova, Charlotte Ford, Robert G. Hatfield, Andres Santos, Jaime Martinez-Urtaza, Tim P. Bean, Craig Baker-Austin, Paul Stebbing   +10 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Advice on animal and public health risks of insects reared on former foodstuffs as raw material for animal feed

Food Risk Assess Europe, Volume 4, Issue 1, January 2026.
Abstract In the coming decades, there is expected to be a sharply increased demand for dietary proteins for humans and animals. As a result, there is an increasing focus on reared insects as a new source of protein. According to the Ministry of Agriculture, Nature and Food Quality (LNV), the use of food chain residual flows such as former foodstuffs as
L.F.F. Kox, D.T.H.M. Sijm
wiley   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Environmental Variables Influence on Spatial Distribution of Bacterial Communities Across the English Channel in Two Main Productive Seasons

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
In the English Channel, the main environmental variables were SPM, POM, PIM, NO2−/NO3+ and salinity in spring and salinity, SPM, Si and Chl‐a in summer. Most of the spring communities had a higher proportion of Bacteroidetes and Proteobacteria, while most of the summer communities had a higher proportion of Proteobacteria, Bacteroidetes, Actinobacteria,
Luen‐Luen Li, Nicolas Delatre, Zéline Hubert, Luis Felipe Artigas, Sébastien Monchy   +4 more
wiley   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla, Carmen Nanclares, Sara Expósito, Grace Gall, Paulo Kofuji, Alfonso Araque, Eduardo D. Martín, Rosario Moratalla   +7 more
wiley   +1 more source