Results 51 to 60 of about 578,223 (240)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

M. caprae in northern Italy: a comprehensive analysis through whole-genome sequencing on the genetic variability in bovine herds

Veterinary Research
Mycobacterium (M.) bovis and M. caprae are the causative agents of bovine tuberculosis (bTB), which is still a concern due to its health implications and economic impact. Although M. caprae is less prevalent than M. bovis among bovine tuberculosis cases,
Cristina Bertasio, Valentina Carta, Giovanni Parisio, Mariagrazia Zanoni, Marco Tamba, Laura Mazzera, Erika Scaltriti, Maria Lodovica Pacciarini, Giovanni Loris Alborali, Daniel Polzer, Annette Nigsch, Romana Steinparzer, Maria Beatrice Boniotti   +12 more
doaj   +1 more source

Introduction and Application of the Interferon-γ Assay in the National Bovine Tuberculosis Control Program in South Korea

Frontiers in Veterinary Science, 2020
Bovine tuberculosis is a chronic disease impacting both public health and the livestock industry. The interferon (IFN)-γ assay has been introduced as an ancillary test for diagnosing bovine tuberculosis to overcome limitations of the skin test.
Yun-Ho Jang, Tae-woon Kim, Min Kyu Jeong, Yoon Jeong Seo, Soyoon Ryoo, Chan Ho Park, Sin seok Kang, Young Ju Lee, Soon-Seek Yoon, Jae Myung Kim   +9 more
doaj   +1 more source

BOVINE AND HUMAN TUBERCULOSIS. [PDF]

JAMA: The Journal of the American Medical Association, 1904
In the last two reports presented by this committee considerable space was devoted to the subject of tuberculosis, and particularly to that phase of it which relates to the transmission of the disease from animals to man. It was shown from a review of the facts obtained by different methods of inquiry that the clinical evidence, the evidence of ...
openaire   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle [PDF]

, 2006
Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. In addition to increasing economic losses, the rise in bovine tuberculosis poses a human health risk. There is an
C. J. Howard, Howard, C J, Hope, J C; id_orcid, P. Sopp, J. C. Hope, Sopp, P   +5 more
core   +1 more source

Molecular Characterization of Mycobacterium tuberculosis Isolates From West of Iran Using Mycobacterial Interspersed Repetitive Unit‐Variable Number Tandem Repeats: A Cross‐Sectional Study

Health Science Reports
Background and Aims Tuberculosis (TB) remains a major global health problem and poses significant challenges for diagnosis and treatment. The World Health Organization (WHO) recommends the use of molecular methods for the diagnosis and genotyping of ...
Mohammad Yazdanmanesh, Keyvan Tadayon, Hossein Kazemian, Nilufar Sadouqi, Nader Mosavari   +4 more
doaj   +1 more source

BOVINE AND HUMAN TUBERCULOSIS. [PDF]

The Lancet, 1888
n ...
openaire   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Matrixlysis, an improved sample preparation method for recovery of Mycobacteria from animal tissue material. [PDF]

PLoS ONE, 2017
Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex, is the main causative agent of bovine tuberculosis in alpine regions. Bacterial culture is the gold standard in bovine tuberculosis diagnostic but takes up to twelve weeks.
Christoph Leth, Ashok Varadharajan, Patrick Mester, Marlis Fischaleck, Peter Rossmanith, Friedrich Schmoll, Maria Fink   +6 more
doaj   +1 more source