Results 71 to 80 of about 859,917 (274)

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source

Risk Factors for Zoonotic Tuberculosis at the Wildlife–Livestock–Human Interface in South Africa

Pathogens, 2019
A cross-sectional study was conducted to investigate the risk factors associated with zoonotic tuberculosis in humans and its transmission to people living at the wildlife−livestock−human interface. A questionnaire was administered to collect
Petronillah R. Sichewo, Anita L. Michel, Jolly Musoke, Eric M.C. Etter   +3 more
doaj   +1 more source

Conservation of White Rhinoceroses Threatened by Bovine Tuberculosis, South Africa, 2016–2017

Emerging Infectious Diseases, 2018
During 2016–2017, when Kruger National Park, South Africa, was under quarantine to limit bovine tuberculosis spread, we examined 35 white and 5 black rhinoceroses for infection.
Michele A. Miller, P. Buss, S. Parsons, Eduard Otto Roos, J. Chileshe, W. Goosen, Louis van Schalkwyk, L. de Klerk-Lorist, M. Hofmeyr, Guy Hausler, Leana Rossouw, Tebogo Manamela, E. Mitchell, R. Warren, P. V. van Helden   +14 more
semanticscholar   +1 more source

Comparative functional genomics and the bovine macrophage response to strains of the Mycobacterium genus [PDF]

, 2014
Mycobacterial infections are major causes of morbidity and mortality in cattle and are also potential zoonotic agents with implications for human health.
Gordon, SV, Killick, KE, MacHugh, DE, Magee, DA, Nalpas, NC, Rue-Albrecht, K   +5 more
core   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

Inside Mycobacterium bovis SB0120 spoligotype circulating in Italy: analysis of the most frequent genotypes by whole genome sequencing

Frontiers in Microbiology
Bovine tuberculosis (bTB) is a chronic inflammatory disease primarily caused by Mycobacterium bovis. The infection affects domestic animals and wildlife, posing a zoonotic risk to humans.
Erika Scaltriti, Karaman Iyad, Maria Beatrice Boniotti, Ilaria Menozzi, Luca Bolzoni, Dorotea Ippolito, Flavia Pruiti Ciarello, Daniela Loda, Mario D’Incau, Mariagrazia Zanoni, Vincenzo Di Marco Lo Presti, Piera Mazzone, Stefano Gavaudan, Maria Lodovica Pacciarini   +13 more
doaj   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

First Insight into Diversity of Minisatellite Loci in Mycobacterium bovis/M. caprae in Bulgaria

Diagnostics, 2023
The aim of this study was to assess the diversity of minisatellite VNTR loci in Mycobacterium bovis/M. caprae isolates in Bulgaria and view their position within global M. bovis diversity. Forty-three M. bovis/M.
Daria Terentieva, Tanya Savova-Lalkovska, Albena Dimitrova, Magdalena Bonovska, Igor Mokrousov, Violeta Valcheva   +5 more
doaj   +1 more source

The challenges of preventing bovine tuberculosis

Bulletin of the World Health Organization, 2018
Bovine tuberculosis destroys livelihoods and is hampering efforts to achieve the End TB Strategy goal of tuberculosis elimination by 2030. Sophie Cousins reports on efforts to stamp out this neglected infectious disease.
S. Cousins
semanticscholar   +1 more source