Results 71 to 80 of about 39,720 (193)

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Two Novel 1,4‐Naphthoquinone Derivatives as Potent Agents Against Multidrug‐Resistant Staphylococcus aureus and Pathogenic Gram‐Positive Bacteria

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song, Haena Lee, Ji‐Hyun Yoon, Hyunkyung Choi, Hakwon Kim, Ki‐Young Kim   +5 more
wiley   +1 more source

Primary multidrug resistant tuberculosis

Lung India, 2007
A 37-year old man presented at our institution with back pain, low-grade fever and weight-loss. X-ray of chest (postero-anterior view) showed multiple opacities with erosion of right 2nd and left 6th ribs.
Sarkar Supriya, Maity G, Mukhopadhyay K, Acharyya Biplab, Ghoshal A   +4 more
doaj  

Exploring health care providers’ engagement in prevention and management of multidrug resistant Tuberculosis and its factors in Hadiya Zone health care facilities: qualitative study

BMC Health Services Research
Background Engagement of healthcare providers is one of the World Health Organization strategies devised for prevention and provision of patient centered care for multidrug resistant tuberculosis.
Bereket Aberham Lajore, Yitagesu Habtu Aweke, Samuel Yohannes Ayanto, Menen Ayele   +3 more
doaj   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Primary multidrug-resistant tuberculosis and its control implications in the State of Amazonas, Brazil: report of 3 cases

Revista da Sociedade Brasileira de Medicina Tropical, 2012
The occurrence of tuberculosis with first-line multidrug resistance leads to the use of alternative medications, often at higher costs, longer treatment periods, and greater clinical complexity.
Marlucia Silva Garrido, Anette Chrusciak Talhari, Irineide Assumpção Antunes, Joycenea da Silva Matsuda, Etelvina das Graças Zaranza, Flor Ernestina Martinez-Espinosa, Samira Bührer-Sékula   +6 more
doaj   +1 more source

Antimicrobial Resistance at the Human–Animal–Environment Interface: A One Health Perspective on Drivers, Transmission, and Public Health Responses

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Antimicrobial resistance (AMR) is a global health threat driven by interconnected antimicrobial use and environmental pressures across human, animal, and ecological systems. This review synthesizes current evidence on the major drivers, transmission pathways, reservoirs, surveillance challenges, and public health responses ...
Nurshad Ali
wiley   +1 more source

One Health Insights From Pteropus medius: Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Environmental and anthropogenic drivers of antibiotic resistance dissemination. The cycle reinforces how anthropogenic inputs, such as sewage, animal dung, hospital effluent, and agricultural runoff bring resistant bacteria and antibiotic residues into soil and water.
Punam Chowdhury, Shah Md Tanvir Khan, Sajal Roy, Md. Shohel Al Faruk   +3 more
wiley   +1 more source

Limited Scope of Shorter Drug Regimen for MDR TB Caused by High Resistance to Fluoroquinolone

Emerging Infectious Diseases, 2019
Resistance to second-line tuberculosis drugs for patients with multidrug-resistant tuberculosis has emerged globally and is a potential risk factor for unfavorable outcomes of shorter duration drug regimens.
Pravin K. Singh, Amita Jain
doaj   +1 more source