Results 81 to 90 of about 39,720 (193)

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source

Social aspects multi-drug resistant tuberculosis

Бюллетень сибирской медицины, 2012
The comparative analysis of features of clinical symptoms, spectrum and the importance of burdening medico-social factors of a tuberculosis of lungs with primary MDR М.
O. V. Filinyuk, O. I. Urazova, Ye. V. Nekrasov, L. N. Buinova, O. V. Kolokolova, I. G. Felker, O. Yu. Khristenko   +6 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Hematological Profiles of Pulmonary Tuberculosis and Multi‐Drug‐Resistant Tuberculosis Patients at Debre Tabor Comprehensive Specialized Hospital, North‐Central Ethiopia: A Comparative Cross‐Sectional Study

Health Science Reports
Background and Aims Tuberculosis is a major infectious disease that affects hematological profiles. However, limited data assess changes in hematological profiles among patients with pulmonary and multidrug‐resistant tuberculosis.
Ayenew Berhan, Bekele Sharew, Andargachew Almaw, Shewaneh Damtie, Biruk Legese, Mulat Erkihun, Ayenew Assefa, Birhanemaskal Malkamu, Getu Abeje, Birhanu Getie, Yenealem Solomon   +10 more
doaj   +1 more source

Hybrid Conjugated Polymer Nanoparticles as a Dual‐Mode Photodynamic–Photothermal Platform for Antibacterial Inactivation

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
ABSTRACT This study explores a light‐activated antimicrobial strategy by developing hybrid nanoparticles (Cn‐TBT‐NPs) composed of the conjugated polymers Cn‐PPV and PCPDTBT, which combine photodynamic and photothermal effects to inactivate Staphylococcus aureus and Escherichia coli.
Hygor Chaves, Cynthia S. A. Caires, Laís F. Aguilera, Regiane G. Lima, Priscila S. Cavalheri, Montcharles S. Pontes, Samuel L. Oliveira, Anderson R. L. Caires   +7 more
wiley   +1 more source

Determinants of multidrug-resistant tuberculosis among adults undergoing treatment for tuberculosis in Tigray Region, Ethiopia: a case–control study

BMJ Open Respiratory Research
Background Multidrug-resistant tuberculosis is a type of tuberculosis that is resistant to at least the first-line antituberculosis drugs namely, rifampicin and isoniazid. However, most of these studies were limited only to a single hospital.
Kidane Zereabruk, Tensay Kahsay, Hiyab Teklemichael, Woldu Aberhe, Abrha Hailay, Guesh Mebrahtom, Gebrewahd Bezabh   +6 more
doaj   +1 more source

Mechanisms of Resistance, Insights From Case Reports, and Future Prospects in Mycobacteriophage Therapy

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Evolution of drug‐resistant mycobacterial infections warrants renewed efforts in identifying more efficient preventive and control strategies as well as alternative treatment options. Interest in phage therapy is regaining significant traction, especially in cases of failed conventional therapy.
Buhari Yusuf, Abdul Malik, Md Shah Alam, Lijie Li, Haftay Abraha Tadesse, Aweke Mulu Belachew, Cuiting Fang, Xirong Tian, Htin Lin Aung, Shuai Wang, Tianyu Zhang   +10 more
wiley   +1 more source

Multidrug-Resistant Tuberculosis [PDF]

New England Journal of Medicine, 2012
Mel, Spigelman, Carolyn, Compton, Jan, Gheuens   +2 more
openaire   +4 more sources

Assessment of Antimicrobial Resistance in M. leprae Strains From Kiribati

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1035-1042, August 2026.
ABSTRACT Objectives Kiribati has one of the highest rates of leprosy worldwide. A nationwide screening and chemoprophylaxis program for household leprosy contacts was introduced in 2018. In 2022, population‐wide screening and rifamycin‐based treatment or chemoprophylaxis for leprosy and tuberculosis was introduced as part of the PEARL and COMBINE ...
Patrick O. Campbell, Temea Bauro, Erei Rimon, Nabura Ioteba, Trevor Anderson, Arturo Cunanan, Taulanga Naniseni, Jacqui Gardner, Emma Trowbridge, Nicholas M. Douglas, Stephen T. Chambers   +10 more
wiley   +1 more source