Results 81 to 90 of about 61,970 (240)

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients.

open access: yes, 2012
Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of the type, number, and duration of drugs used ...
Neel Gandhi (139419)   +450 more
core   +1 more source

Issues of Tuberculosis Drug-Resistance in Kharkiv Region and in Ukraine

open access: yesInfusion & Chemotherapy, 2019
Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problems in the world. That’s why the purpose of our study was to investigate the dynamics of the incidence of multidrug-resistant and ...
O.S. Shevchenko, O.O. Pohorielova
doaj   +1 more source

Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications

open access: yesContact Dermatitis, EarlyView.
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti   +7 more
wiley   +1 more source

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

open access: yesNew England Journal of Medicine, 2009
The diarylquinoline TMC207 offers a new mechanism of antituberculosis action by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and shows bactericidal activity in patients who have drug-susceptible pulmonary tuberculosis.In the first stage of a two-stage, phase 2 ...
Diacon, A. H.   +21 more
openaire   +3 more sources

Comparison of Mycobacterium tuberculosis drug susceptibility using solid and liquid culture in Nigeria. [PDF]

open access: yes, 2013
BACKGROUND: This study compares Mycobacterium tuberculosis culture isolation and drug sensitivity testing (DST) using solid (LJ) and liquid (BACTEC-MGIT-960) media in Nigeria.
Luis E Cuevas   +27 more
core   +1 more source

Clinical Features and Treatment Outcomes of Patients with Drug-Resistant and Drug-Sensitive Tuberculosis: A Historical Cohort Study in Porto Alegre, Brazil.

open access: yesPLoS ONE, 2016
PurposeTo evaluate the clinical features and treatment outcomes of patients with pulmonary tuberculosis, stratified by level of drug resistance.MethodsThis was a historical cohort study based on data from the II National Anti-Tuberculosis Drug Resistance
Vania Celina Dezoti Micheletti   +2 more
doaj   +1 more source

Pharmacotherapy for multidrug resistant tuberculosis.

open access: yesJournal of pharmacology & pharmacotherapeutics, 2012
The current global concern in the treatment of tuberculosis (TB) is the emergence of resistance to the two most potent drugs namely, isoniazid and rifampicin. Emergence of multidrug resistance tuberculosis (MDR-TB) is now a health problem faced by most of the developing countries as well as developed countries across the globe.
Chhabra, Naveen   +3 more
openaire   +2 more sources

Factors associated with multidrug-resistant tuberculosis

open access: yesIMC Journal of Medical Science, 2009
This case control study was conducted in selected centers of Dhaka City from March to July 2008 to determine the association of multidrug-resistant tuberculosis with the attributes related to treatment and socio-economic condition of tuberculosis ...
Md Nurul Amin   +3 more
doaj  

Assessment of Antimicrobial Resistance in M. leprae Strains From Kiribati

open access: yesTropical Medicine &International Health, EarlyView.
ABSTRACT Objectives Kiribati has one of the highest rates of leprosy worldwide. A nationwide screening and chemoprophylaxis program for household leprosy contacts was introduced in 2018. In 2022, population‐wide screening and rifamycin‐based treatment or chemoprophylaxis for leprosy and tuberculosis was introduced as part of the PEARL and COMBINE ...
Patrick O. Campbell   +10 more
wiley   +1 more source

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