Results 91 to 100 of about 149,015 (244)

Serum vitamin D concentration is inversely associated with matrix metalloproteinase‐9 level in periodontal diseases

Journal of Periodontology, EarlyView.
Abstract Background The aim of this study was to investigate the potential association between vitamin D deficiency and matrix metalloproteinase‐9 (MMP‐9) levels in gingival crevicular fluid (GCF) across various periodontal health and disease statuses.
Yeşim Ayhan Yıldırım, Ayla Ozturk, Fatma Doğruel, Hatice Saraçoğlu, Cevat Yazıcı   +4 more
wiley   +1 more source

Diabetes and pulmonary tuberculosis: a global overview with special focus on the situation in Asian countries with high TB-DM burden

Global Health Action, 2017
Background: The double burden of tuberculosis (TB) and diabetes mellitus (DM) is hitting certain Asian countries harder than other areas. In a global estimate, 15% of all TB cases could be attributable to DM, with 40% of those cases coming from India and
Chunlan Zheng, Minhui Hu, Feng Gao
doaj   +1 more source

A Survey on Methotrexate Prescribing and Monitoring Practices in Ireland

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Methotrexate, originally an anti‐neoplastic agent, is now extensively used at lower doses in dermatology and rheumatology for chronic inflammatory conditions. While its safety is supported by routine blood monitoring, there remains variability in recommended monitoring frequency, folic acid supplementation, liver function testing ...
Ji Fung Yong, Fei Lai, Claire Quigley, Li Jie Helena Yoo, Claudine Howard‐James, Fatma Al Hosni, Gregg Murray, Anne‐Marie Tobin   +7 more
wiley   +1 more source

MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy

Nature Communications, 2018
How Mycobacterium tuberculosis (Mtb) escapes autophagy-mediated clearance is poorly understood. Here, Liu et al. show that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy ...
Feng Liu, Jianxia Chen, Peng Wang, Haohao Li, Yilong Zhou, Haipeng Liu, Zhonghua Liu, Ruijuan Zheng, Lin Wang, Hua Yang, Zhenling Cui, Fei Wang, Xiaochen Huang, Jie Wang, Wei Sha, Heping Xiao, Baoxue Ge   +16 more
doaj   +1 more source

The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae

mLife, EarlyView.
Abstract Gram‐negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high‐priority pathogens. One strategy that has increased is the use of antibiotic enhancers, which can re‐empower abandoned or poorly active antibiotics against the resistant strain of interest.
Emma Forest, Jordan Lehoux, Alexandre Guy, Thierry Durand, Stéphane Audebert, Luc Camoin, Christopher D. Spilling, Céline Crauste, Stéphane Canaan, Jean Michel Brunel, Jean‐Michel Bolla, Jean‐François Cavalier   +11 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosis

European Journal of Medical Research
Tuberculosis is a serious global health burden, resulting in millions of deaths each year. Several circulating cell subsets in the peripheral blood are known to modulate the host immune response to Mycobacterium tuberculosis (Mtb) infection in different ...
Li Wang, Ya He, Peng Wang, Hai Lou, Haipeng Liu, Wei Sha   +5 more
doaj   +1 more source

Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks. [PDF]

Sci Rep, 2020
Asay BC, Edwards BB, Andrews J, Ramey ME, Richard JD, Podell BK, Gutiérrez JFM, Frank CB, Magunda F, Robertson GT, Lyons M, Ben-Hur A, Lenaerts AJ.   +12 more
europepmc   +1 more source

Investigating Tuberculosis Dynamics Under Various Control Strategies: A Comprehensive Analysis Using Real Statistical Data

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In the present investigation, a mathematical model with vaccination, treatment, and environmental impact under real data is presented. Initially, we present the model without any interventions, followed by an examination of its equilibrium points.
Bashir Al‐Hdaibat, Mahmoud H. DarAssi, Irfan Ahmad, Muhammad Altaf Khan, Reem Algethamie   +4 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source