Results 61 to 70 of about 273,523 (312)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine

Nature Communications
Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis (M. tuberculosis), but the underlying mechanism remains unknown.
Cheng Peng, Yuanna Cheng, Mingtong Ma, Qiu Chen, Yongjia Duan, Shanshan Liu, Hongyu Cheng, Hua Yang, Jingping Huang, Wenyi Bu, Chenyue Shi, Xiangyang Wu, Jianxia Chen, Ruijuan Zheng, Zhonghua Liu, Zhe Ji, Jie Wang, Xiaochen Huang, Peng Wang, Wei Sha, Baoxue Ge, Lin Wang   +21 more
doaj   +1 more source

Current landscape of exosomes in tuberculosis development, diagnosis, and treatment applications

Frontiers in Immunology
Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (MTB), remains one of the most prevalent and deadly infectious diseases worldwide. Currently, there are complex interactions between host cells and pathogens in TB. The onset,
Xuezhi Sun, Wei Li, Li Zhao, Ke Fan, Fenfen Qin, Liwen Shi, Feng Gao, Chunlan Zheng   +7 more
doaj   +1 more source

Evaluation of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells for discrimination of active tuberculosis

BMC Infectious Diseases, 2022
Background Active tuberculosis (ATB) originates from primary Mycobacterium tuberculosis (MTB) infection or reactivation of latent tuberculosis. Besides bacteriological examination, MTB-reactive immunocytes detection can be an alternative testing for ...
Yong Fang, Na Wang, Liang Tang, Xiao-Jun Yang, Yuan Tang, Lin Li, Wen-Fei Wu, Bo Su, Wei Sha   +8 more
doaj   +1 more source

PhD Thesis. Computer-Aided Assessment of Tuberculosis with Radiological Imaging: From rule-based methods to Deep Learning [PDF]

arXiv, 2022
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb.) that produces pulmonary damage due to its airborne nature. This fact facilitates the disease fast-spreading, which, according to the World Health Organization (WHO), in 2021 caused 1.2 million deaths and 9.9 million new cases.
arxiv  

Pulmonary tuberculosis and some underlying conditions in Golestan Province of Iran, during 2001-2005 [PDF]

, 2009
Context: Pulmonary tuberculosis has been a major health problem in Golestan province of Iran. Aims: This descriptive cross-sectional study was performed to evaluate the frequency of coexisting medical conditions and their effects on some epidemiologic ...
Dashti, M., Golsha, R., Najafi, L., Rezaei, S.R., Roshandel, G., Shafiee, A.   +5 more
core  

Single‐Cell Sequencing‐Guided Annotation of Rare Tumor Cells for Deep Learning‐Based Cytopathologic Diagnosis of Early Lung Cancer

Advanced Science, EarlyView.
This study presents an innovative method to generate high‐quality, objectively annotated cytology datasets without relying on expert involvement. Large‐scale single‐cell DNA sequencing is used as an objective ground truth of cell annotation for generating an accurate, unbiased dataset of exfoliated tumor cells from bronchoalveolar lavage cytology ...
Yichun Zhao, Ruoran Qiu, Zhuo Wang, Yunyun Li, Xu Yang, Yanlin Li, Xiaohan Shen, Yun Liu, Ziqiang Chen, Qihan You, Qihui Shi   +10 more
wiley   +1 more source

Veterinary nanomedicine: Pros and cons

Veterinary Medicine and Science, Volume 9, Issue 1, Page 494-506, January 2023., 2023
Abstract In recent years, nanotechnology has improved life with continuous growth in different fields. Nanoparticles can be employed in industry, imaging, engineering, and various biomedical filed because of their special physicochemical properties like rapid, effective, highly specific solutions, higher stability, biodegradability, biocompatibility ...
Fariba Jafary, Shima Motamedi, Isaac Karimi   +2 more
wiley   +1 more source

Host-directed therapy against mycobacterium tuberculosis infections with diabetes mellitus

Frontiers in Immunology
Tuberculosis (TB) is caused by the bacterial pathogen Mycobacterium tuberculosis (MTB) and is one of the principal reasons for mortality and morbidity worldwide.
Li Zhao, Ke Fan, Xuezhi Sun, Wei Li, Fenfen Qin, Liwen Shi, Feng Gao, Chunlan Zheng   +7 more
doaj   +1 more source

Diagnostic yield of Xpert MTB/RIF on contrast-enhanced ultrasound-guided pleural biopsy specimens for pleural tuberculosis

International Journal of Infectious Diseases, 2021
Background: A 3-year prospective study was conducted to evaluate the efficacy of Xpert MTB/RIF (Xpert) in the diagnosis of pleural tuberculosis (pTB) on contrast -enhanced ultrasound (CEUS)-guided pleural biopsy specimens. Method: Patients suspected with
Wenwen Sun, Yiming Zhou, Wenting Li, Yin Wang, Kunlong Xiong, Zhemin Zhang, Lin Fan   +6 more
doaj