Results 141 to 150 of about 769,512 (313)

Tuberculosis [PDF]

Journal of Midwifery & Women's Health, 2021
openaire   +2 more sources

Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide–Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis

ChemMedChem, EarlyView.
Molecular docking shows that ligands 8 (a–i) adopt a U‐shaped geometry in the InhA active site, enabling stronger interactions than 7 (j–r). Surprisingly, both sets display similar potency, indicating that factors like electronic effects or solvation also influence anti‐TB activity.
Mukanda Gedeon Kadima, Sahil Mishra, Gobind Kumar, Pule Seboletswe, Afsana Kajee, Ankit, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Rajshekhar Karpoormath, Parvesh Singh   +10 more
wiley   +1 more source

Synthesis of a Conformationally Fixed Bicyclomarin Derivative

ChemMedChem, EarlyView.
The synthesis of a new bicyclic derivative of cyclomarin is described. Cyclomarin is a marine cyclopeptide with excellent antituberculosis activity. The synthesis of the linear heptapeptide and the two macrolactamizations proceed smoothly. Based on an X‐ray structure of cyclomarin bound to ClpC1, a new conformationally fixed, bicyclic cyclomarin ...
Jennifer Greve, Alexander F. Kiefer, Uli Kazmaier   +2 more
wiley   +1 more source

Pattern of ethionamide susceptibility and its association with isoniazid resistance among previously treated tuberculosis patients from India

Brazilian Journal of Infectious Diseases
Rajagopalan Lakshmi, Vanaja Kumar, Murugesan Baskaran, Syam Sundar, Fathima Rahman, Nagamaiah Selvakumar, Ranjani Ramachandran   +6 more
doaj   +1 more source

New Structure Activity Relationship Insight into the Role of the C‐3 Extension on Rifamycin Antimycobacterial Activity

ChemMedChem, EarlyView.
Rifamycin analogues with variably functionalized C‐3 extensions provide new insight into the role of this region for MTb inhibitory activity. In addition to potentially optimizing target engagement, this region can also be used to modulate physicochemical properties, an important consideration for optimizing antimycobacterial activity.
Clinton G. L. Veale, Ewelina Smolarz, Aleksandra Leśniewska, Krystian Pyta, Piotr Przybylski   +4 more
wiley   +1 more source

On the Action of some Essential Oils and Other Volatile Substances on the Growth of the Bacillus Tuberculosis and in the Treatment of Phthisis [PDF]

, 1899
William Murrell
openalex   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Analysis of clinical and bronchoscopic features of multidrug-resistant tracheobronchial tuberculosis. [PDF]

BMC Infect Dis
Li J, Li X, Qiu L, Huang G, Huang J, Liu Z, Ke X, Wang X, Gao W, Li G.   +9 more
europepmc   +1 more source

THE NECESSITY FOR A MORE THOROUGH CONTROL OF THE MILK SUPPLY IN COMBATING SURGICAL TUBERCULOSIS IN CHILDHOOD [PDF]

, 1913
Harold Stiles
openalex   +1 more source

Itinerant curriculum theory: People's theory against the field's epistemicidal ethos

The Curriculum Journal, EarlyView.
Abstract The field of curriculum studies suffers from a glaring theoretical impasse. Much of this impasse has been rightly attributed to the triumphalism of the neoliberal wave that has massacred the educational hemisphere with policies and practices that reduce pedagogy to an instrumentalist praxis directly associated with the thirsty desires and ...
João M. Paraskeva
wiley   +1 more source