Results 141 to 150 of about 1,198,187 (379)

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Poorly immunogenic pathogens are a major cause of infectious disease. We chemically modified the surface of such a pathogen (Staphylococcus aureus) with a synthetic adjuvant to boost immunogenicity. “Adjuvanted” S. aureus induced improved immune responses in macrophages compared to unadulterated bacteria.
Nikolas Duszenko, Danny M. van Willigen, Anton Bunschoten, Aldrik H. Velders, Meta Roestenberg, Fijs W. B. van Leeuwen   +5 more
wiley   +1 more source

METHODS OF MULTIDIMENSIONAL STATISTIC PROCESSING OF DATA APPLIED TO FIND REGULARITIES IN THE COURSE OF TUBERCULOSIS IN SIBERIAN AND FAR EASTERN FEDERAL DISTRICTS

Туберкулез и болезни лёгких, 2018
The article presents results of multi-dimensional analysis of 83 rates, calculated on the basis of federal and sectoral reports on tuberculosis in 21 regions of Siberian and Far Eastern Federal Districts, which were collected from 2006 to 2016.
I. O. Meshkov, O. V. Revyakina, V. A. Krasnov, Ya. Sh. Shvarts, T. I. Petrenko   +4 more
doaj   +1 more source

Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis [PDF]

, 2015
Tuberculosis (TB) remains a global pandemic and drug resistance is rising. Multicellular granuloma formation is the pathological hallmark of Mycobacterium tuberculosis infection.
Brilha, S, Elkington, P, Friedland, JS, Mauri, F, Saraiva, L, Sathyamoorthy, T, Tezera, L, Walker, N, Wilkinson, R   +8 more
core   +2 more sources

Tuberculosis of the Placenta: A Historical Study with Especial Reference to the Nature of the Earliest Lesions Produced by the Tubercle Bacillus [PDF]

, 1907
A. S. Warthin
openalex   +1 more source

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

Social features of the families of children and adolescents suffering from respiratory tuberculosis

Туберкулез и болезни лёгких, 2018
The article describes one of the topical issues related to the study of social aspects of children tuberculosis that is the justification of substantial criteria of for defining social status of different families.
N. V. Zolotovа, A. A. Аkhtyamovа, E. S. Ovsyankinа, I. Yu. Petrаkovа, A. Yu. Khitevа   +4 more
doaj   +1 more source

Effect on short‐term outcomes of the COVID‐19 pandemic following laparoscopic distal gastrectomy and low anterior resection for gastric and rectal cancer: A retrospective study using the Japanese National Clinical Database, 2018–2022

Annals of Gastroenterological Surgery, EarlyView.
Mortality and anastomotic leakage, two very important complications assessed in SMR, did not worsen during the pandemic compared to prepandemic levels. In Japan, laparoscopic surgery was safe and unaffected by the COVID‐19 pandemic even in 2022, when the epidemic spread.
Masafumi Inomata, Hideki Endo, Tomonori Akagi, Hidefumi Shiroshita, Shigeki Yamaguchi, Susumu Eguchi, Norihito Wada, Yukinori Kurokawa, Yosuke Seki, Yoshiharu Sakai, Hiroyuki Yamamoto, Yoshihiro Kakeji, Yuko Kitagawa, Akinobu Taketomi, Masaki Mori   +14 more
wiley   +1 more source

Underestimated latent tuberculosis infection burden among school contacts in China: a cross-sectional study

Archives of Public Health
Background Previous research has indicated a low tuberculin skin tests (TST) strong positive rate in school tuberculosis (TB) screening implemented by community-level medical and health care institutions in China.
Jin Yin, Mei Wang, Chengguo Wu, Yaling Shi, Ying Liu, Ya Yu, Qian Su, Zhengyu Zhang, Xueyong Huang, Xiaoshuang Zhang, Jun Fan, Bo Wu   +11 more
doaj   +1 more source

DELAYED OUTCOMES OF SURGICAL TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS RESIDING IN THE REGION WITH HIGH PREVALENCE OF THE DISEASE

Туберкулез и болезни лёгких, 2017
Retrospective cohort study was conduced in order to investigate the efficiency of surgical treatment in pulmonary tuberculosis patients residing in the region with high prevalence of the disease.
M. V. Reykhrud, D. V. Krasnov, V. A. Krasnov, N. G. Grischenko, T. I. Petrenko   +4 more
doaj   +1 more source