Results 191 to 200 of about 1,339,212 (357)

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium Tuberculosis: Progress Toward Novel Antitubercular Agents

open access: yesChemMedChem, EarlyView.
A series of 42 homoisoflavones were synthesized and evaluated against Mycobacterium tuberculosis (Mtb). Three derivatives showed potent inhibition of Mtb strains. Evaluation in infected macrophages revealed promising intracellular activity, where one derivative featuring a nitrofuranyl and piperidine group emerges as the most promising.
Sanderson D. Calixto   +12 more
wiley   +1 more source

Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor

open access: yesChemMedChem, EarlyView.
Balinatunfib (BNF) is an oral small molecule undergoing clinical trials that stabilizes an asymmetrical TNFα (tumor necrosis factor) trimer. By locking TNF in a nonsignaling conformation, BNF achieves biologic‐like efficacy in preclinical arthritis models, potentially transforming the management of TNF‐driven inflammation. Most diseases are accompanied
Alexander Dömling, Tad A. Holak
wiley   +1 more source

Patient experiences of tuberculosis treatment deferral after a trace Xpert Ultra result: a prospective cohort study. [PDF]

open access: yesInfect Dis Poverty
Visek C   +11 more
europepmc   +1 more source

Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors

open access: yesChemPlusChem, EarlyView.
A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou   +4 more
wiley   +1 more source

The Polythene Pack Operation for Pulmonary Tuberculosis [PDF]

open access: bronze, 1951
Huw M. L. Davies   +2 more
openalex   +1 more source

Epidemiology of Tuberculosis in Iran (2001-08) [PDF]

open access: yes
Background and Objective: The characterization of any disease have important role for the evaluation and control strategy and programming of diseases. This study was done to determine the epidemiology of Tuberculosis in Iran during 2001-08. Materials and
ارسنگ, شهرام   +2 more
core  

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