Results 81 to 90 of about 1,231,953 (350)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Latent Profile Analysis and Influencing Factors of Medication-Related Burden in Multidrug-Resistant Tuberculosis Patients in Chengdu, China

Patient Preference and Adherence
Yuanyuan Li,1,* Qiaolin Yu,1,* Rong Yao,2 Xiaoyi Yang,2 Bin Wan,3 Xia Zhao,3 Yinping Hu,1 Yan Zhou,2 Li Dai,4 Xiaoli Liu,5 Enchun Xie,6 Fang Huang,7 Fanghui Xie,2 Zhouli Guo5 1The First Department of Tuberculosis, the Public Health ...
Li Y, Yu Q, Yao R, Yang X, Wan B, Zhao X, Hu Y, Zhou Y, Dai L, Liu X, Xie E, Huang F, Xie F, Guo Z   +13 more
doaj  

PREVALENCE AND DIVERSITY OF NONTUBERCULOUS MYCOBACTERIA IN DIFFERENT REGIONS OF THE RUSSIAN FEDERATION

Инфекция и иммунитет, 2018
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V. Ustinova, T. Smirnova, E. Larionova, I. Andrievskaya, E. Kiseleva, S. Andreevskaya, L. Chernousova   +6 more
doaj   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

MONITORING OF SPECIES DIVERSITY OF NON-TUBERCULOSIS MYCOBACTERIA IN THE SOME RUSSIAN REGIONS USING DNA-STRIPS OF GENOTYPE MYCOBACTERIUM CM/AS (HAIN LIFESCIENCE, GERMANY)

Туберкулез и болезни лёгких, 2017
Goal of study: to define species of non-tuberculosis mycobacteria, isolated from the respiratory tract of the patients from various Russian regions using DNA strips for identification of non-tuberculous mycobacteria.Materials and methods.
T. G. Smirnovа, S. N. Аndreevskаya, E. E. Lаrionovа, I. Yu. Аndrievskаya, V. V. Ustinovа, L. N. Chernousovа   +5 more
doaj   +1 more source

Primary thyroid gland tuberculosis: a conundrum in a child [PDF]

, 2020
Sonam Sharma, Rachit Sharma
openalex   +1 more source

Type I interferons in tuberculosis: Foe and occasionally friend

Journal of Experimental Medicine, 2018
Type I interferons have been implicated in the pathogenesis of tuberculosis. Herein, Moreira-Teixeira et al. discuss mechanistic and contextual factors that determine the role of type I interferons during Mycobacterium tuberculosis infection, from human ...
Lúcia Moreira-Teixeira, K. Mayer-Barber, A. Sher, A. O’Garra   +3 more
semanticscholar   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

MicroRNA AND TUBERCULOSIS

Инфекция и иммунитет, 2018
In 2015, more than 10% of tuberculosis (TB)-related deaths were attributable to M. tuberculosis with multiple drug-resistance (MDR-TB) and extensively drug-resistance (XDR-TB) (WHO 2016).
V. V. Eremeev, V. V. Evstifeev, G. S. Shepelkova, A. E. Ergeshova, M. A. Bagirov   +4 more
doaj   +1 more source

Tuberculosis [PDF]

Journal of Midwifery & Women's Health, 2021
openaire   +2 more sources