Results 81 to 90 of about 1,339,212 (357)

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

CHANGES IN PSYCHOLOGICAL AND EMOTIONAL STATE OF PULMONARY TUBERCULOSIS CHANGES WITH ANTI-TUBERCULOSIS CHEMOTHERAPY ACCOMPANIED BY PSYCHOLOGICAL SUPPORT

Туберкулез и болезни лёгких, 2016
The article describes the investigation of psychological and emotional state of pulmonary tuberculosis patients belonging to various categories having in-patient treatment.
G. V. Baranova, N. V. Zolotova, V. V. Strel'tsov, N. Yu. Kharitonova, A. A. Akhtyamova, I. A. Vasilieva   +5 more
doaj  

Tuberculosis transmission to young children in a South African community: modeling household and community infection risks.

, 2010
BACKGROUND: Tuberculosis transmission is determined by contact between infectious and susceptible individuals. A recent study reported a 4% annual risk of child tuberculosis infection in a southern African township.
Bekker, Linda-Gail, Hargrove, John, Johnstone-Robertson, Simon, Lawn, Stephen D, Middelkoop, Keren, Uys, Pieter, Wood, Robin   +6 more
core   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

B-lymphocyte aggregation in the lung tissue is a pathogenic factor in experimental infection caused by Mycobacterium avium

Туберкулез и болезни лёгких, 2016
When infecting the lungs with Mycobacterium avium of B6 line mice genetically susceptible to this infection the compact aggregates (follicles) of B-lymphocytes are formed with the peak at the 11-13th week after the infection.
I. A. Linge, A. V. Dyatlov, E. V. Kondratieva, A. S. Аpt, T. K. Kondratieva   +4 more
doaj   +1 more source

Tuberculosis and gender: exploring the patterns in a case control study in Malawi. [PDF]

, 2004
BACKGROUND: In many populations there is an excess of tuberculosis in young women and older men. We explored possible explanations for these patterns, concentrating on human immunodeficiency virus (HIV) status, pregnancy, smoking, cooking smoke exposure,
Crampin, AC, Fine, PEM, Floyd, S, Glynn, JR, Malema, SS, Mwaungulu, FD, Mwinuka, VK, Ngwira, BMM, Warndorff, DK   +8 more
core  

A re-evaluation of M. prototuberculosis [PDF]

, 2006
It has been suggested that a group of smooth tubercle bacilli, isolated from patients with tuberculosis and associated with Djibouti, East Africa, along with the seven species and subspecies that are traditional members of the Mycobacterium tuberculosis ...
Marianne Manchester, Noel H Smith
core   +3 more sources

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

METHODS OF MULTIDIMENSIONAL STATISTIC PROCESSING OF DATA APPLIED TO FIND REGULARITIES IN THE COURSE OF TUBERCULOSIS IN SIBERIAN AND FAR EASTERN FEDERAL DISTRICTS

Туберкулез и болезни лёгких, 2018
The article presents results of multi-dimensional analysis of 83 rates, calculated on the basis of federal and sectoral reports on tuberculosis in 21 regions of Siberian and Far Eastern Federal Districts, which were collected from 2006 to 2016.
I. O. Meshkov, O. V. Revyakina, V. A. Krasnov, Ya. Sh. Shvarts, T. I. Petrenko   +4 more
doaj   +1 more source

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source