Computational prognostic evaluation of Alzheimer’s drugs from FDA-approved database through structural conformational dynamics and drug repositioning approaches [PDF]
Scientific Reports, 2023 Drug designing is high-priced and time taking process with low success rate. To overcome this obligation, computational drug repositioning technique is being promptly used to predict the possible therapeutic effects of FDA approved drugs against multiple
Mubashir Hassan +4 more
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Ensemble-Based Virtual Screening Led to the Discovery of Novel Lead Molecules as Potential NMBAs [PDF]
MoleculesNeuromuscular blocking agents (NMBAs) are routinely used during anesthesia to relax skeletal muscle. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels; NMBAs can induce muscle paralysis by preventing the neurotransmitter ...
Yi Zhang +3 more
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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing [PDF]
Current Research in ToxicologyAnimal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling.
Jacob W. Fleming +13 more
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Adsorption and inhibition analysis of aconitine and tubocurarine alkaloids as eco-friendly inhibitors of pitting corrosion in ASTM – A47 low carbon steel in HCl acid environmen [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 The research on the adsorption and inhibition analysis of aconitine alkaloid (ACA) and tubocurarine alkaloid (TBA) as eco-friendly inhibitors of pitting corrosion in ASTM – A47 low carbon steel in HCl acid was carried out under the following ...
Benedict Ushaka Ugi +5 more
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Ars Pharmaceutica, 2023 Introduction: Histamine is an endogenous ligand which exerts its biological actions by binding to 4 subtypes of histamine receptors (HR). Its effects on the gastrointestinal tract are complex being the dominant effect contraction of muscle cells ...
Andreé Salvatierra
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Indonesian Journal of Chemistry, 2022 Corrosion is an enormous challenge in all sectors of the economy, especially to those working with metals. The research on the adsorption and inhibition analysis of aconitine alkaloid (ACA) and tubocurarine alkaloid (TBA) as eco-friendly inhibitors of ...
Benedict Ushaka Ugi +7 more
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IBRO Reports, 2020 Correlated spontaneous activity propagating over a wide region of the central nervous system is expressed during a specific period of embryonic development.
Yoko Momose-Sato, Katsushige Sato
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Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. [PDF]
PLoS ONE, 2013 We aimed to develop and validate a reliable method for stable long-term recordings of EEG activity in zebrafish, which is less prone to artifacts than current invasive techniques.
Anselm A Zdebik +5 more
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A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. [PDF]
PLoS Biology, 2011 Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of ...
Marijke Brams +8 more
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British Journal of Anaesthesia, 1976 Tubocurarine, given as a single bolus, may be used safely for neuromuscular blockade in the neonate. The recommended dose is 250 mug/kg at birth, increasing to 500 mug/kg at 28 days of age. This dose should be reduced in the event of prematurity, acidosis or hypothermia, or when certain antibiotics or inhalation anaesthetic agents are present in the ...
E J, Bennett +4 more
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